{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:28Z","timestamp":1787016088194,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T00:00:00Z","timestamp":1537660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n                    Primary pulmonary histiocytic sarcoma (PHS) has been reported, but is not well characterized. The aim of this retrospective study was to describe clinical characteristics, characterize prognostic factors and report the outcome of a larger group of dogs with primary PHS. Medical records of dogs diagnosed with primary PHS at 11 institutions were retrospectively reviewed. Thirty\u2010seven dogs were included; 13 received CCNU\u2010based chemotherapy alone, 18 received surgery and adjuvant CCNU\u2010based chemotherapy, 3 received medical management alone and 3 dogs received surgery alone. The overall median progression free survival (PFS) and the median survival (overall survival [OS]) were 197 and 237 days, respectively. Measurable responses were noted in dogs receiving only chemotherapy; however, responses were not durable with PFS (91\u2009days) and OS times (131\u2009days) shorter than overall medians. Dogs that received surgery and chemotherapy had significantly prolonged PFS (276\u2009days,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001) and OS (374\u2009days,\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.001), compared with dogs not receiving surgery. As only three dogs undergoing surgery did not receive chemotherapy, it is not possible to determine the contribution of chemotherapy as an adjuvant to surgery. Dogs without evidence of intra\u2010thoracic metastatic disease were much more likely to undergo surgery (odds ratio\u2009=\u20097.04;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u20090.018). While the presence of metastasis or clinical signs at diagnosis negatively impacted PFS, only the former negatively impacted OS. These data imply that dogs presenting with PHS amenable to surgery (ie, no clinical evidence of metastasis) benefit from surgical intervention; however, the lack of a comparable surgery alone group precludes assessment of the efficacy of post\u2010surgical adjuvant chemotherapy.\n                  <\/jats:p>","DOI":"10.1111\/vco.12437","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T02:45:16Z","timestamp":1537757116000},"page":"658-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Primary pulmonary histiocytic sarcoma in dogs: A retrospective analysis of 37 cases (2000\u20102015)"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9842-3121","authenticated-orcid":false,"given":"Katelyn W.","family":"Marlowe","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia S.","family":"Robat","sequence":"additional","affiliation":[{"name":"Veterinary Emergency Service\/Veterinary Specialty Center Middleton Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, Veterinary Clinical Sciences Department, University of Georgia Athens Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3852-0127","authenticated-orcid":false,"given":"Angela","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services, Royal Veterinary College London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maude","family":"Touret","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Centre V\u00e9t\u00e9rinaire Laval Laval Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Husbands","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, University of Minnesota St. Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Vail","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Wisconsin\u2010Madison Madison Wisconsin"},{"name":"Carbone Cancer Center Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300101"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-74"},{"key":"e_1_2_6_4_1","first-page":"1041","article-title":"Canine histiocytic neoplasia: an overview","volume":"48","author":"Fulmer AK","year":"2007","journal-title":"Can 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