{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T10:44:01Z","timestamp":1770979441205,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H04598"],"award-info":[{"award-number":["15H04598"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16J06655"],"award-info":[{"award-number":["16J06655"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>Canine histiocytic sarcoma is an aggressive, fatal neoplastic disease with a poor prognosis. Lomustine is generally accepted as the first\u2010line systemic therapy, although this compound does not provide complete regression. Therefore, research into a novel approach against canine histiocytic sarcoma is needed. However, anti\u2010tumour effects of oncolytic therapy using reovirus against histiocytic sarcoma are unknown. Here, we showed that reovirus has oncolytic activity in canine histiocytic sarcoma cell lines in vitro and in vivo. We found that reovirus can replicate and induce caspase\u2010dependent apoptosis in canine histiocytic sarcoma cell lines. A single intra\u2010tumoural injection of reovirus completely suppressed the growth of subcutaneously grafted tumours in NOD\/SCID mice. Additionally, we demonstrated that susceptibility to reovirus\u2010induced cell death was attributable to the extent of expression of type I interferons induced by reovirus infection in vitro. In conclusion, oncolytic reovirus appears to be an effective treatment option for histiocytic sarcoma, and therefore warrants further investigation in early clinical trials.<\/jats:p>","DOI":"10.1111\/vco.12468","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T08:34:58Z","timestamp":1550133298000},"page":"184-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells"],"prefix":"10.1111","volume":"17","author":[{"given":"Masaya","family":"Igase","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Diagnostics and Therapeutics, The United Graduate School of Veterinary Science Yamaguchi University  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuha","family":"Shousu","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine Yamaguchi University  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Fujiki","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diagnostics and Therapeutics, Joint Faculty of Veterinary Medicine Yamaguchi University  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine Yamaguchi University  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0054-7730","authenticated-orcid":false,"given":"Makoto","family":"Bonkobara","sequence":"additional","affiliation":[{"name":"Laboratory of Veterinary Clinical Pathology, Faculty of Veterinary Medicine Nippon Veterinary and Life Science University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung C.","family":"Hwang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diagnostics and Therapeutics, The United Graduate School of Veterinary Science Yamaguchi University  Yamaguchi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt","family":"Coffey","sequence":"additional","affiliation":[{"name":"Oncolytics Biotech Inc.  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