{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T12:57:51Z","timestamp":1789736271908,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This retrospective study aimed to evaluate factors associated with survival and to compare characteristics between tumour localizations in dogs with urinary transitional cell carcinoma (TCC) that underwent whole\u2010body computed tomography (CT) at diagnosis. Dogs with histologically confirmed TCC that received medical therapy between 2010 and 2017 were included; dogs that underwent surgery or radiotherapy for the primary tumour were excluded. According to the CT findings, primary tumour localization (classified into the Bladder, Urethra and Bladder and Urethra groups), prostate involvement, iliosacral lymphadenomegaly, sternal lymphadenomegaly and metastasis to the bone and lung were evaluated for survival analysis. CT at diagnosis revealed iliosacral lymphadenomegaly, sternal lymphadenomegaly, bone metastasis and lung metastasis in 47.7%, 18.5%, 24.6% and 35.4% of the 65 included dogs, respectively. The overall median survival time was 196 days. On multivariable analysis, TCC localization (hazard ratio [HR], 1.90;\n                    <jats:italic>P<\/jats:italic>\n                    = .037), bone metastasis (HR, 2.76;\n                    <jats:italic>P<\/jats:italic>\n                    = .013) and sternal lymphadenomegaly (HR, 3.56;\n                    <jats:italic>P<\/jats:italic>\n                    = .004) were significantly associated with survival. Compared to the Bladder group (n = 16), the Urethra group (n = 26) had higher metastasis rates to the bone (6.3% vs 42.3%;\n                    <jats:italic>P<\/jats:italic>\n                    = .045) and lung (6.3% vs 46.2%;\n                    <jats:italic>P<\/jats:italic>\n                    = .022). The survival time was shorter in the Urethra group than in the Bladder group (121.5 vs 420\u2009days;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001), and it was similar only in female dogs (247 vs 420 days;\n                    <jats:italic>P<\/jats:italic>\n                    = .031). These findings suggest that whole\u2010body CT could be valuable for predicting the prognosis in urinary TCC.\n                  <\/jats:p>","DOI":"10.1111\/vco.12483","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T04:48:36Z","timestamp":1555994916000},"page":"385-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Survival analysis in dogs with urinary transitional cell carcinoma that underwent whole\u2010body computed tomography at diagnosis"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7781-764X","authenticated-orcid":false,"given":"Ryota","family":"Iwasaki","sequence":"first","affiliation":[{"name":"Animal Medical Centre, Faculty of Applied Biological Sciences Gifu University  Gifu 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