{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:05:06Z","timestamp":1778605506230,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment options for dogs with metastatic (stage III) splenic hemangiosarcoma are limited. A doxorubicin\u2010based chemotherapy regimen is commonly administered; however, there are no published data to support this practice. The aim of this study was to investigate the impact of maximum\u2010tolerated\u2010dose chemotherapy (MTD), metronomic chemotherapy (MC) and no adjuvant treatment on outcome in dogs with stage III splenic hemangiosarcoma undergoing splenectomy. Medical records of dogs with stage III splenic hemangiosarcoma that underwent splenectomy followed by MTD chemotherapy, MC or no adjuvant treatment were retrieved. Time to progression (TTP), survival time (ST) and toxicity were evaluated. One hundred three dogs were identified: 23 received adjuvant MTD, 38 MC and 42 were not medically treated. Overall median TTP and ST were 50 (95% confidence interval [CI], 39\u201061) and 55 days (95% CI, 43\u201066), respectively. Dogs treated with adjuvant MTD had a significantly longer TTP and ST compared with dogs receiving MC (median TTP, 134 vs 52 days, <jats:italic>P<\/jats:italic> = .025; median ST, 140 vs 58 days, <jats:italic>P<\/jats:italic> = .023, respectively). Dogs treated by splenectomy only had the shortest median TTP (28 days) and ST (40 days). However, treatment\u2010related adverse events (AEs) were significantly more frequent in the MTD group (<jats:italic>P<\/jats:italic> = .017). The outcome for dogs with metastatic splenic hemangiosarcoma is poor. While MTD showed greater efficacy compared to MC, toxicity was higher in this group. Treatment\u2010related AEs need to be carefully balanced against this modest survival prolongation when offering adjuvant MTD to dogs with advanced stage hemangiosarcoma.<\/jats:p>","DOI":"10.1111\/vco.12519","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T13:52:49Z","timestamp":1561729969000},"page":"537-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Adjuvant anthracycline\u2010based vs metronomic chemotherapy vs no medical treatment for dogs with metastatic splenic hemangiosarcoma: A multi\u2010institutional retrospective study of the Italian Society of Veterinary Oncology"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"Laura","family":"Marconato","sequence":"first","affiliation":[{"name":"Centro Oncologico Veterinario  Bologna 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Veterinaria Tibaldi  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-0366","authenticated-orcid":false,"given":"Damiano","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Mesto","sequence":"additional","affiliation":[{"name":"Centro Medico Veterinario BMVet  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ombretta","family":"Capitani","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Agnoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna 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