{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:37:28Z","timestamp":1788352648332,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    High\u2010grade canine mast cell tumours (HG\u2010MCT) have a high rate of locoregional relapse. In this study, dogs with HG\u2010MCT treated with radiation therapy (RT) were retrospectively evaluated to determine the benefit associated with treating the locoregional lymph nodes (LNs). Forty\u2010two dogs were included. Variables assessed for association with overall survival (OS) and progression\u2010free survival (PFS) included WHO stage, tumour location and size, LN irradiation (prophylactic, therapeutic or none), LN treatment (yes or no), LN status at RT (metastatic or nonmetastatic) and RT intent (definitive vs palliative). Lower\u2010stage disease at irradiation was significantly associated with prolonged median PFS (425 vs 125\u2009days for stage 0 vs 1\u20104), and OS (615 vs 314\u2009days for stage 0 vs 1\u20104). Having any LN treatment and definitive RT were both significantly associated with prolonged OS. In order to evaluate the role of LN irradiation, dogs were divided into subgroups: (a) stage 0 at irradiation with no LN treatment (n = 14), (b) stage 0 at irradiation with prophylactic LN irradiation (n = 6), (c) stage 0 at irradiation but previously stage 2 (n = 5) and (d) stage &gt;0 at irradiation (n = 17). Prophylactic LN irradiation significantly prolonged PFS (&gt;2381 vs 197\u2009days; group B vs A). Interestingly, dogs that were stage 2 and had LN treatment (C) had prolonged OS vs dogs with negative LNs and no LN treatment (A) (1908 vs 284\u2009days;\n                    <jats:italic>P<\/jats:italic>\n                    = .012). This study confirms that prophylactic and therapeutic LN irradiation in dogs with HG\u2010MCT is beneficial and improves outcome.\n                  <\/jats:p>","DOI":"10.1111\/vco.12541","type":"journal-article","created":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T12:24:00Z","timestamp":1568204640000},"page":"239-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Treating the locoregional lymph nodes with radiation and\/or surgery significantly improves outcome in dogs with high\u2010grade mast cell tumours"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7266-5501","authenticated-orcid":false,"given":"Susan E.","family":"Mendez","sequence":"first","affiliation":[{"name":"University of Pennsylvania, Department of Clinical Sciences &amp; Advanced Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Drobatz","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Department of Clinical Sciences &amp; Advanced Medicine  Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilian E.","family":"Duda","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Department of Clinical Sciences &amp; Advanced Medicine  Philadelphia PA"},{"name":"University of Pennsylvania, Penn Vet Cancer Center  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"White","sequence":"additional","affiliation":[{"name":"The Oncology Service  Leesburg Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsay","family":"Kubicek","sequence":"additional","affiliation":[{"name":"Angell Animal Medical Center  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-4199","authenticated-orcid":false,"given":"Karin U.","family":"Sorenmo","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Penn Vet Cancer Center  Philadelphia Pennsylvania"},{"name":"University of Pennsylvania, Department of Biomedical Sciences  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-2362-5.00020-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.154.24.743"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.11.1464"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.11.018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100503"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814521638"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1973.tb06891.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0442.1967.tb00235.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5557"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.193"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.224.79"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.68.581"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00185.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01897.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00354.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.1998.tb00326.x"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12541","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12541","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12541","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T19:14:27Z","timestamp":1694027667000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/vco.12541"],"URL":"https:\/\/doi.org\/10.1111\/vco.12541","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"assertion":[{"value":"2019-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}