{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:08:10Z","timestamp":1782900490355,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Splenectomy followed by adjuvant chemotherapy is commonly used to treat canine splenic haemangiosarcoma (HSA), although it is unclear if different treatment protocols may have a similar efficacy. The objective of this retrospective study was to assess outcome in dogs with stage I and II splenic HSA treated with either first\u2010line adjuvant anthracycline (AC) or metronomic (MC)\u2010based chemotherapy protocols, by comparing median time to progression (TTP) and median survival time (MST). Medical records of nine institutions were searched for dogs diagnosed with stage I and II splenic HSA that underwent adjuvant treatment with AC\u2010 or MC\u2010based protocols following splenectomy. Patients treated with MC following AC were included in an additional group (AMC). Ninety\u2010three dogs were included: 50 in the AC group, 23 in the AMC group and 20 in the MC group. The overall MST was 200\u2009days (range 47\u20103352) and the overall median TTP was 185\u2009days (range 37\u20101236). The median TTP of stage I dogs was significantly longer compared to stage II dogs (338 vs 151\u2009days, respectively, <jats:italic>P<\/jats:italic> = .028). When adjusting for treatment type, the MST was 154\u2009days for the AC group (range 47\u20103352\u2009days),  338\u2009days for the AMC group (range 79\u20101623\u2009days) and 225 days for the MC group (range 57\u2010911 days). The difference in MST and median TTP was not found to be statistically significant between treatment groups. This study suggests that adjuvant MC in canine splenic HSA may result in a similar outcome when compared to other treatment protocols. Further studies are warranted to confirm these findings.<\/jats:p>","DOI":"10.1111\/vco.12548","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T18:04:20Z","timestamp":1571940260000},"page":"43-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Retrospective comparison of first\u2010line adjuvant anthracycline vs metronomic\u2010based chemotherapy protocols in the treatment of stage I and II canine splenic haemangiosarcoma"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5081-2440","authenticated-orcid":false,"given":"Elisabetta","family":"Treggiari","sequence":"first","affiliation":[{"name":"Centro Specialistico Veterinario  Milan Italy"},{"name":"Willows Veterinary Centre and Referral Service  Solihull West Midlands UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F.","family":"Borrego","sequence":"additional","affiliation":[{"name":"Hospital Auna Especialidades Veterinarias  Paterna Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Gramer","sequence":"additional","affiliation":[{"name":"Davies Veterinary Specialists, Higham Gobion  Herts UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Valenti","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Malpensa  Samarate, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-2061","authenticated-orcid":false,"given":"Aaron","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Finotello","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science, Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Toni","sequence":"additional","affiliation":[{"name":"Willows Veterinary Centre and Referral Service  Solihull West Midlands UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla","family":"Laomedonte","sequence":"additional","affiliation":[{"name":"Centro Specialistico Veterinario  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Centro Specialistico Veterinario  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.238.4.472"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870401600606"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci2040388"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-34-5-417"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01033.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2003.00024.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.231.10.1550"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.247.4.393"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1996.tb02085.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00266.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03019.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","unstructured":"Veterinary Cooperative Oncology Group common terminology criteria for adverse events (VCOG\u2010CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1.2016;14(4):417\u201346.","DOI":"10.1111\/vco.283"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5603"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050591"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12193"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12796"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-6540"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12926"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2011.0753.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12203"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00280.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12635"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12292"},{"issue":"9","key":"e_1_2_8_25_1","first-page":"967","article-title":"Canine visceral hemangiosarcoma treated with surgery alone or surgery and doxorubicin: 37 cases (2005\u20102014)","volume":"59","author":"Batschinski K","year":"2018","journal-title":"Can Vet J"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12548","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12548","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12548","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T06:22:26Z","timestamp":1694067746000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/vco.12548"],"URL":"https:\/\/doi.org\/10.1111\/vco.12548","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]},"assertion":[{"value":"2019-03-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}