{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:37:54Z","timestamp":1790714274182,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canine B\u2010cell lymphoma is a clinically heterogenous disease; however, it is generally treated as a single disease entity. The purpose of this clinical trial was to prospectively evaluate na\u00efve canine B\u2010cell lymphoma patients using histopathology, flow cytometry (FC) and a standardized chemotherapy protocol to better define subsets of this disease that may respond differently to treatment. Sixty\u2010four dogs with na\u00efve multicentric B\u2010cell lymphoma were treated with a standardized 19\u2010week CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy protocol. Most of the dogs (84.3%) were diagnosed with diffuse large B\u2010cell lymphoma (DLBCL), followed by nodal marginal zone (7.8%), small B\u2010cell (4.7%), Burkitt\u2010like (1.6%) and follicular lymphoma (1.6%). FC confirmed the diagnosis of B\u2010cell lymphoma in all cases. There were no clear phenotyping differences between the subtypes of B\u2010cell lymphoma detectable by our FC panel. The histologic subtypes in this study exhibited a range of forward scatter values on flow cytometry, but all of the DLBCL cases were higher than a value of 469, while the only cases with a lower forward scatter value were follicular lymphoma and diffuse small B\u2010cell lymphoma. Dogs with DLBCL had a significantly better objective response rate to the CHOP protocol (96.3%) than the non\u2010DLBCL subtypes (70%, <jats:italic>P<\/jats:italic> = .024). The median progression\u2010free survival time for patients with DLBCL (233\u2009days) was significantly longer than that of all other histopathologic subgroups combined (163\u2009days, <jats:italic>P<\/jats:italic> = .0005).<\/jats:p>","DOI":"10.1111\/vco.12553","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T16:04:50Z","timestamp":1572883490000},"page":"342-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Prospective evaluation of flow cytometric characteristics, histopathologic diagnosis and clinical outcome in dogs with na\u00efve B\u2010cell lymphoma treated with a 19\u2010week CHOP protocol"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9597-9658","authenticated-orcid":false,"given":"Amber","family":"Wolf\u2010Ringwall","sequence":"first","affiliation":[{"name":"Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynelle","family":"Lopez","sequence":"additional","affiliation":[{"name":"Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Elmslie","sequence":"additional","affiliation":[{"name":"VRCC Veterinary Specialty and Emergency Hospital  Englewood Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Fowler","sequence":"additional","affiliation":[{"name":"Aspen Meadow Veterinary Specialists  Longmont Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Lori","sequence":"additional","affiliation":[{"name":"Animal Emergency and Specialty Center  Parker Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Sfiligoi","sequence":"additional","affiliation":[{"name":"Wheat Ridge Animal Hospital and Veterinary Specialists  Wheat Ridge Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Skope","sequence":"additional","affiliation":[{"name":"VCA Alameda East Veterinary Hospital  Denver Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Arnold","sequence":"additional","affiliation":[{"name":"VRCC Veterinary Specialty and Emergency Hospital  Englewood Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas H.","family":"Thamm","sequence":"additional","affiliation":[{"name":"Flint Animal Cancer Center, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"E. 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