{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:53:32Z","timestamp":1793444012349,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>No standard of care is currently recognized for treatment of canine prostatic carcinoma (PC). This retrospective study assesses outcome following definitive\u2010intent, intensity\u2010modulated radiation therapy (RT) in dogs with PC. Medical records review was performed, including 18 patients from four institutions undergoing definitive\u2010intent intensity\u2010modulated radiotherapy to treat PC. Diagnosis was incidental in 7\/18 (39%) patients. Five dogs (28%) had evidence of metastasis to loco\u2010regional lymph nodes at diagnosis. Seventeen patients received concurrent non\u2010steroidal anti\u2010inflammatory drugs; 15\/18 (83%) patients received maximally\u2010tolerated dose (MTD) chemotherapy, with variable drugs and protocols employed. Total prescribed radiation dose ranged from 48 to 54\u2009Gy (median 50\u2009Gy) delivered as daily doses of 2.5\u20102.8 Gy. One patient was euthanized prior to completing radiotherapy. Acute toxicity was observed in nine patients; Grade 1\u20102 diarrhoea was the most common toxicity observed. Suspected late toxicity (urethral stricture, ureteral stricture and hindlimb oedema) was observed in three patients. Median event\u2010free survival (EFS) following RT was 220\u2009days, and median overall survival was 563\u2009days. Local progression occurred in seven patients at a median of 241\u2009days. Median overall survival was significantly longer in incidentally diagnosed dogs (581 vs 220\u2009days in symptomatic dogs,<jats:italic>P<\/jats:italic>= .042). EFS was significantly longer in patients treated with MTD chemotherapy (241 vs 25\u2009days,<jats:italic>P<\/jats:italic>&lt;\u2009.001), and significantly shorter in patients presenting with evidence of metastatic disease (109\u2009days) vs those without (388\u2009days,<jats:italic>P<\/jats:italic>= .008). These findings suggest that definitive\u2010intent radiotherapy is a valuable treatment option for local control of canine PC with moderate risk of toxicity.<\/jats:p>","DOI":"10.1111\/vco.12561","type":"journal-article","created":{"date-parts":[[2019,12,7]],"date-time":"2019-12-07T08:17:50Z","timestamp":1575706670000},"page":"381-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Definitive\u2010intent intensity\u2010modulated radiation therapy for treatment of canine prostatic carcinoma: A multi\u2010institutional retrospective study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3452-5895","authenticated-orcid":false,"given":"Jillian Z.","family":"Walz","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Veterinary Medical Center The Ohio State University Columbus Ohio"},{"name":"Department of Oncology MSPCA\u2010Angell Animal Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noopur","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Veterinary Medical Center The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Van Asselt","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison Madison Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie J.","family":"Poirier","sequence":"additional","affiliation":[{"name":"Animal Cancer Centre, Ontario Veterinary College University of Guelph Guelph Ontario Canada"},{"name":"Massey University School of Veterinary Science Palmerston North New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine University of California\u2010Davis Davis California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-6273","authenticated-orcid":false,"given":"Laura","family":"Selmic","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, Veterinary Medical Center The Ohio State University Columbus 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