{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:08:15Z","timestamp":1787652495253,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Published outcomes for dogs with specifically high\u2010grade mast cell tumours (MCTs), controlled for clinical stage, are few. Clinical outcomes for 49 dogs with Kiupel high\u2010grade, clinical stage I, cutaneous MCTs were evaluated. Median survival time (MST) was 1046\u2009days; 1 and 2\u2010year survival rates were 79.3% and 72.9%, respectively. At study end 24 dogs had died, 23 dogs were alive (median follow\u2010up 980\u2009days) and 2 dogs were lost to follow\u2010up. Death was considered MCT\u2010related in 14 of 20 dogs with a known cause of death. Local tumour recurrence developed in nine dogs (18.4%); regional lymph node metastasis occurred in six dogs (12.2%); and a new MCT developed in 15 dogs (30.1%). Tumour location, histologic margin size and use of chemotherapy did not affect MST; increasing mitotic count (\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.001) and increasing tumour diameter (\n                    <jats:italic>P<\/jats:italic>\n                    =\u2009.024) were independently negatively prognostic. Six dogs that developed lymph node metastasis after surgery had worse MST (451\u2009days) than 42 dogs that did not develop metastasis (1645\u2009days); (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u2009.001). Our study suggests that dogs with local surgical control of clinical stage I histologically high Kiupel grade cutaneous MCT may have a long survival time; especially those with smaller tumours and a lower mitotic count. Our results suggest that evaluation of staging information and mitotic count may be equally helpful as histologic grading when making a prognosis; and highlight the importance of not relying on histologic grade alone when predicting survival for dogs with MCT.\n                  <\/jats:p>","DOI":"10.1111\/vco.12565","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T05:39:22Z","timestamp":1578548362000},"page":"402-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Retrospective outcome evaluation for dogs with surgically excised, solitary Kiupel high\u2010grade, cutaneous mast cell tumours"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8402-4100","authenticated-orcid":false,"given":"Antony S.","family":"Moore","sequence":"first","affiliation":[{"name":"Veterinary Oncology Consultants  Wauchope New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela E.","family":"Frimberger","sequence":"additional","affiliation":[{"name":"Veterinary Oncology Consultants  Wauchope New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Taylor","sequence":"additional","affiliation":[{"name":"Vetnostics  North Ryde New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neill","family":"Sullivan","sequence":"additional","affiliation":[{"name":"IDEXX Laboratories  Sydney New South Wales 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