{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:25:12Z","timestamp":1770225912533,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,22]],"date-time":"2020-03-22T00:00:00Z","timestamp":1584835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment of epithelial sinonasal tumours in cats is not commonly reported. In the newer reports, palliative radiation protocols have been described more often than definitive\u2010intent protocols. In this multi\u2010institutional retrospective study, we included 27 cats treated with single\u2010modality radiotherapy. Cats were irradiated using 10 daily fractions of 4.2\u2009Gy. Three cats (11.1%) experienced a complete clinical response and 17 (63%) had a partial clinical response. Stable clinical disease was noted in three cats (11.1%). Four cats (14.8%) showed progression within 3\u2009months following treatment. The median time to progression for all cases was 269\u2009days (95 % confidence intervals [CI]: 225; 314). The proportion of cats free of progression at 1 and 2\u2009years was 24% (95% CI: 22%; 26%) and 5% (95% CI: 5%; 6%), respectively. None of the prognostic factors evaluated were predictive of outcome (anaemia, tumour volume at the time of staging, modified Adams stage, intracranial involvement, facial deformity, epistaxis, inappetence or weight loss). Median overall survival (OS) for all deaths was 452\u2009days (95% CI: 334; 571). The proportion of cats alive at 1 and 2\u2009years was 57% (95% CI: 37%; 77%) and 27% (95% CI: 25%; 29%), respectively. Surprisingly, cats with epistaxis had a longer median OS of 828\u2009days (95% CI: 356; 1301) compared to 296\u2009days (95% CI: 85; 508) in cats without epistaxis, (<jats:italic>P<\/jats:italic>= .04, Breslow). Radiation therapy used as a single modality for the treatment of feline sinonasal carcinoma improved clinical signs and was well tolerated but progression within a year was common.<\/jats:p>","DOI":"10.1111\/vco.12583","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T15:02:25Z","timestamp":1583420545000},"page":"626-633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Definitive\u2010intent radiotherapy for sinonasal carcinoma in cats: A multicenter retrospective assessment"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7847-6039","authenticated-orcid":false,"given":"Katerina","family":"Stiborova","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Small Animal Department, Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-9005","authenticated-orcid":false,"given":"Valeria S.","family":"Meier","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Small Animal Department, Vetsuisse Faculty University of Zurich Zurich Switzerland"},{"name":"Department of Physics University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-0528","authenticated-orcid":false,"given":"Marilia","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Turek","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin\u2010Madison Madison Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie J.","family":"Poirier","sequence":"additional","affiliation":[{"name":"Animal Cancer Centre, Ontario Veterinary College University of Guelph Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Laliberte","sequence":"additional","affiliation":[{"name":"Animal Cancer Centre, Ontario Veterinary College University of Guelph Guelph Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-2722","authenticated-orcid":false,"given":"Carla","family":"Rohrer Bley","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Small Animal Department, Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,22]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"339","article-title":"Tumors of the nose and Paranasal sinuses in cats \u2010 32 cases with comparison to a National Database (1977 through 1987)","volume":"27","author":"Cox NR","year":"1991","journal-title":"J Am Animal Hos Asso"},{"key":"e_1_2_8_3_1","first-page":"308","volume-title":"Tumors of Respiratory Tract. 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