{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:23:19Z","timestamp":1787016199676,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Canine lymphoma, as the most common haematopoietic malignancy, encompasses a group of heterogeneous diseases and even within the T\u2010cell immunophenotype, differences in clinical presentation and responses to treatment exist. The aim of this retrospective study was to determine outcomes and prognostic factors of 107 dogs with multicentric non\u2010indolent T\u2010cell lymphoma (TCL) receiving lomustine\u2010based (70%) and non\u2010lomustine\u2010based (30%) treatment. The majority were Labradors, Boxers, mixed\u2010breed dogs and Dogue de Bordeaux. Eighty\u2010six percent were substage b, 77% had mediastinal involvement, 15% had suspected bone marrow involvement and 12% had other extra\u2010nodal sites of disease. The overall response rate to induction therapy was 80%; dogs receiving procarbazine in the induction protocol (\n                    <jats:italic>P<\/jats:italic>\n                    = .042), dogs with neutrophil concentration below 8.7\u2009\u00d7\u200910e\n                    <jats:sup>9<\/jats:sup>\n                    \/L (\n                    <jats:italic>P<\/jats:italic>\n                    = .006) and mitotic rate below 10 per 5 high power field (\n                    <jats:italic>P<\/jats:italic>\n                    = .013), had greater response rates. Median progression\u2010free survival (PFS) for the first remission was 105\u2009days; lack of expression of CD3 on flow cytometry (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.0001) and pretreatment with steroid (\n                    <jats:italic>P<\/jats:italic>\n                    = .012) were significantly associated with shorter PFS. Median overall survival time (OST) was 136\u2009days; co\u2010expression of CD79a (\n                    <jats:italic>P<\/jats:italic>\n                    = .002), lack of CD3 expression on flow cytometry, presence of anaemia (\n                    <jats:italic>P<\/jats:italic>\n                    = .007), and monocytopenia (\n                    <jats:italic>P<\/jats:italic>\n                    = .002) were predictive of shorter OST. Multicentric non\u2010indolent TCL in dogs is an aggressive cancer with new possible prognostic factors.\n                  <\/jats:p>","DOI":"10.1111\/vco.12589","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T10:25:45Z","timestamp":1584008745000},"page":"656-663","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Clinicopathological characteristics and prognostic factors for canine multicentric non\u2010indolent T\u2010cell lymphoma: 107 cases"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-0135","authenticated-orcid":false,"given":"Katarzyna","family":"Purzycka","sequence":"first","affiliation":[{"name":"Queen Mother Hospital for Animals, Royal Veterinary College University of London North Mymms UK"},{"name":"Anderson Moores Veterinary Specialists The Granary, Bunstead Barns Winchester 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UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lara\u2010Garcia","sequence":"additional","affiliation":[{"name":"Queen Mother Hospital for Animals, Royal Veterinary College University of London North Mymms UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0133.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<480::AID-CNCR2820660314>3.0.CO;2-X"},{"key":"e_1_2_8_4_1","first-page":"1179","article-title":"Histologic classification and immunophenotyping of canine non\u2010Hodgkin's lymphomas: unexpected high frequency of T cell lymphoma with B cell morphology","volume":"22","author":"Teske E","year":"1994","journal-title":"Exp Hematol"},{"key":"e_1_2_8_5_1","first-page":"807","article-title":"Assessment of potential doubling time (Tpot), 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