{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:16Z","timestamp":1787016076217,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T00:00:00Z","timestamp":1589673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thirty dogs with macroscopic plasma cell tumours (PCTs) were treated with radiation therapy (RT). Twelve patients were treated with palliative\u2010intent prescriptions (range, 4\u201010 Gy\/fraction (median, 7 Gy\/fraction) for a total dose of 20 to 35\u2009Gy (median total dose 30\u2009Gy). Eighteen patients received definitive\u2010intent prescriptions (range, 3.0\u20104.2 Gy\/fraction (median, 3 Gy\/fraction) for a total dose of 42 to 54\u2009Gy (median total dose 48\u2009Gy). Involved sites included the oral cavity, skin, multiple myeloma (MM)\u2010associated lytic bone lesions, bone (solitary osseous plasmacytoma; SOP), nasal cavity, larynx, retrobulbar space, lymph node and rectum. Ninety\u2010five percent of evaluable dogs had a complete (CR; 16\/22) or partial response (PR; 5\/22). Patients with MM experienced significant analgesia. The median progression\u2010free survival (PFS) was 611\u2009days (range: 36\u20102001\u2009days). Events in the non\u2010MM cases included in\u2010field progression (5\/26, 19%) and disseminated disease (5\/26, 19%). The median survival time (MST) for all dogs was 697\u2009days (range: 71\u20102075\u2009days), and when only non\u2010MM cases were considered, MST was 771\u2009days (range: 71\u20102075\u2009days). Fourteen patients were alive without disease progression or had died of unrelated causes. Achievement of a PR was associated with an inferior PFS and MST as compared with CR. Palliative\u2010intent RT was associated with inferior MST as compared with definitive\u2010intent RT. RT is a useful therapeutic modality for PCTs and tumour responses are often complete and durable, with protracted survivals. The optimal radiation dose and schedule are yet to be defined.<\/jats:p>","DOI":"10.1111\/vco.12600","type":"journal-article","created":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T09:33:15Z","timestamp":1587288795000},"page":"718-726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Response and outcome following radiation therapy of macroscopic canine plasma cell tumours"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4884-8196","authenticated-orcid":false,"given":"James","family":"Elliott","sequence":"first","affiliation":[{"name":"North Carolina State University, College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayme","family":"Looper","sequence":"additional","affiliation":[{"name":"Louisiana State University, School of Veterinary Medicine Baton Rouge Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Keyerleber","sequence":"additional","affiliation":[{"name":"Tufts University, Cummings School of Veterinary Medicine North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Turek","sequence":"additional","affiliation":[{"name":"University of Wisconsin, School of Veterinary Medicine Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Blackwood","sequence":"additional","affiliation":[{"name":"University of Liverpool, Small Animal Teaching Hospital Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Henry","sequence":"additional","affiliation":[{"name":"Cornell University, College of Veterinary Medicine Ithaca New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-4560","authenticated-orcid":false,"given":"Tracy","family":"Gieger","sequence":"additional","affiliation":[{"name":"North Carolina State University, College of Veterinary Medicine Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,17]]},"reference":[{"issue":"11","key":"e_1_2_8_2_1","first-page":"1288","article-title":"Prognostic factors for multiple myeloma in the dog","volume":"188","author":"Matus RE","year":"1986","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2019.07.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb01140.x"},{"issue":"7","key":"e_1_2_8_5_1","first-page":"694","article-title":"Immunoglobulin A multiple myeloma with cutaneous involvement in a 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