{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:27:05Z","timestamp":1787498825296,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Localized histiocytic sarcoma may occur as a primary lesion in periarticular tissues of large appendicular joints. Treatment options for the primary lesion include radical surgical excision, radiation therapy (RT), or both, in combination with chemotherapy for potential systemic metastases. In an effort to better characterize the time to progression (TTP) following surgical vs non\u2010surgical approaches for periarticular histiocytic sarcoma (PAHS), a contemporary European population of affected dogs was retrospectively surveyed. Medical records were queried for newly\u2010diagnosed PAHS cases undergoing surgery (predominantly limb amputation) or RT followed by systemic chemotherapy. Of 49 dogs, 34 underwent RT and 15 underwent surgery. All dogs received adjuvant chemotherapy. There was no statistically significant difference in TTP or overall survival between groups. The median TTP was 336\u2009days for the operated dogs and 217\u2009days for the irradiated dogs (\n                    <jats:italic>P<\/jats:italic>\n                    = .117). The median overall survival time was 398\u2009days for the operated dogs and 240\u2009days for the irradiated dogs (\n                    <jats:italic>P<\/jats:italic>\n                    = .142). On multi\u2010variable analysis, the variables significantly associated with an increased risk of both tumour progression and tumour\u2010related death were regional lymph node and distant metastasis at admission. Survival and local control rates following RT may be comparable to radical resection. These data may better inform shared decision\u2010making processes between multi\u2010disciplinary care providers and owners.\n                  <\/jats:p>","DOI":"10.1111\/vco.12609","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T15:03:49Z","timestamp":1589295829000},"page":"778-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Outcome comparison between radiation therapy and surgery as primary treatment for dogs with periarticular histiocytic sarcoma: An Italian Society of Veterinary Oncology study"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"Laura","family":"Marconato","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  BO Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-2736","authenticated-orcid":false,"given":"Silvia","family":"Sabattini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  BO Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Buchholz","sequence":"additional","affiliation":[{"name":"Small Animal Clinic Hofheim  Hofheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerry","family":"Polton","sequence":"additional","affiliation":[{"name":"North Downs Specialist Referrals  Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Finotello","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Science Institute of Veterinary Science, University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Martano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4260-1491","authenticated-orcid":false,"given":"Michael","family":"Willman","sequence":"additional","affiliation":[{"name":"Division of Small Animal Internal Medicine, Department of Companion Animals and Horses University of Veterinary Medicine of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Massari","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Nervianese  Nerviano MI Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Agnoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  BO 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Radiation Oncology, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2006.00090.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-66"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12059"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3415\/VCOT-07-05-0054"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12354"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12338"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2007.00292.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.1.90"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2004.0053b.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12032"},{"key":"e_1_2_8_12_1","unstructured":"International Commission on Radiation Units and Measurements.Prescribing Recording and Reporting Photon Beam Therapy(Report 50). Bethesda MD; 1993."},{"key":"e_1_2_8_13_1","unstructured":"International Commission on Radiation Units and Measurements.Prescribing Recording and Reporting Photon Beam Therapy(Report 62 Supplement to ICRU Report 50). Bethesda MD; 1999."},{"key":"e_1_2_8_14_1","unstructured":"International Commission on Radiation Units and Measurements.Prescribing Recording and Reporting Photon\u2010Beam Intensity\u2010Modulated Radiation Therapy (IMRT)(Report 83). Oxford: Oxford University Press; 2010."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12722"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2011.01882.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12145"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-74"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12609","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12609","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T08:11:46Z","timestamp":1693815106000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/vco.12609"],"URL":"https:\/\/doi.org\/10.1111\/vco.12609","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"2020-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}