{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:35:37Z","timestamp":1792168537027,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,26]],"date-time":"2020-07-26T00:00:00Z","timestamp":1595721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["2204\u2010T"],"award-info":[{"award-number":["2204\u2010T"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA213149"],"award-info":[{"award-number":["R01CA213149"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Optical coherence tomography (OCT) uses near\u2010infrared light waves to generate real\u2010time, high\u2010resolution images on the microscopic scale similar to low power histopathology. Previous studies have demonstrated the use of OCT for real\u2010time surgical margin assessment for human breast cancer. The use of OCT for canine mammary tumours (CMT) could allow intra\u2010operative visualisation of residual tumour at the surgical margins. The purpose of this study was to assess OCT imaging for the detection of incomplete tumour resection following CMT surgery. We hypothesized that the OCT images would have comparable features to histopathological images of tissues at the surgical margins of CMT resections along with a high sensitivity of OCT detection of incomplete surgical excision of CMT. Thirty surgical specimens were obtained from nineteen client\u2010owned dogs undergoing surgical resection of CMT. OCT image appearance and characteristics of adipose tissue, skin, mammary tissue and mammary tumour at the surgical margins were distinct and different. The OCT images of normal and abnormal tissues at the surgical margins were utilized to develop a dataset of OCT images for observer evaluation. The sensitivity and specificity for ex vivo images were 83.3% and 82.0% (observer 1) and 70.0% and 67.9% (observer 2). The sensitivity and specificity for in vivo images were 70.0% and 89.3% (observer 1) and 76.7% and 67.9% (observer 2). These results indicate a potential use of OCT for surgical margin assessment for CMT to optimize surgical intervention and clinical outcomes. Improved training and experience of observers may improve sensitivity and specificity.<\/jats:p>","DOI":"10.1111\/vco.12632","type":"journal-article","created":{"date-parts":[[2020,6,20]],"date-time":"2020-06-20T07:49:33Z","timestamp":1592639373000},"page":"697-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumours"],"prefix":"10.1111","volume":"19","author":[{"given":"Carolina","family":"Fabelo","sequence":"first","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-6273","authenticated-orcid":false,"given":"Laura E.","family":"Selmic","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Cheh","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"},{"name":"Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-7202","authenticated-orcid":false,"given":"Jonathan P.","family":"Samuelson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Medicine University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Reagan","sequence":"additional","affiliation":[{"name":"Department of Surgery Seattle Veterinary Specialists\u2010Downtown  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kalamaras","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Wavreille","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences, College of Veterinary Medicine Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-8514","authenticated-orcid":false,"given":"Guillermo L.","family":"Monroy","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"},{"name":"Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Marjanovic","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"},{"name":"Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"},{"name":"Carle Illinois College of Medicine University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A.","family":"Boppart","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"},{"name":"Beckman Institute for Advanced Science and Technology University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"},{"name":"Carle Illinois College of Medicine University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"},{"name":"Department of Electrical and Computer Engineering University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"},{"name":"Cancer Center at Illinois University of Illinois at Urbana\u2010Champaign  Champaign Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985818806968"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2011.01816.x"},{"key":"e_1_2_9_4_1","unstructured":"KutzlerM.. Overview of Mammary Tumors\u2010Reproductive System. Available from:www.merckvetmanual.com\/reproductive-system\/mammary-tumors\/mammary-tumors-in-dogs-and-cats. Merck Veterinary Manual;2020."},{"key":"e_1_2_9_5_1","first-page":"455","article-title":"Canine mammary tumours as a model study human breast cancer: most recent findings","volume":"466","author":"Queiroga FL","year":"2011","journal-title":"In Vivo"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197008)26:2<419::AID-CNCR2820260225>3.0.CO;2-U"},{"key":"e_1_2_9_7_1","first-page":"439","article-title":"Population\u2010based incidence of mammary tumours in some dog breeds","volume":"57","author":"Moe L","year":"2001","journal-title":"J Reprod Fertil"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22633"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12448"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810389316"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.208.1.9646796"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004649901081"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:BREA.0000018401.13609.54"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0798-861"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.jbo.22.12.121711"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2017.09.018"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350618803245"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.jbo.19.5.056001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22654"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3816\/CBC.2005.n.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3480-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10460"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12092"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985817698208"},{"key":"e_1_2_9_26_1","unstructured":"HaahrM. True random integer generator: true random number service. Randomness and Integrity Services Ltd. RANDOM.ORG Web site.https:\/\/www.random.org\/. Accessed March 10 2010."},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2004.12.009"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470906514"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.240.10.1181"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810393258"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4665-2"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-0464.Real-time"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13305"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1364\/boe.5.003417"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1364\/boe.9.006519"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.40099"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12632","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T09:52:53Z","timestamp":1693216373000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,26]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/vco.12632"],"URL":"https:\/\/doi.org\/10.1111\/vco.12632","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,26]]},"assertion":[{"value":"2020-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}