{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:25:36Z","timestamp":1788877536250,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Perioperative administration of desmopressin has shown to significantly decrease rates of local recurrence and metastasis, and increase survival times in dogs with grade II and III mammary carcinomas. The objective of this study was to compare the oncologic outcome of cats with mammary carcinoma treated with bilateral mastectomy with or without perioperative administration of desmopressin. Medical records from nine veterinary institutions were searched to identify cats diagnosed with mammary carcinoma treated with bilateral mastectomy. Sixty cats treated with single\u2010session or staged bilateral mastectomy were included. There were no significant differences in oncologic outcomes found between cats treated and not treated with desmopressin. No adverse effects were seen in any of the cats treated with perioperative desmopressin. Postoperative complications occurred in 18 cats (38.3%) treated with single\u2010session bilateral mastectomy and in three cats (23.1%) treated with staged bilateral mastectomy (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.48). Histologic grade and a modification of a proposed five\u2010stage histologic staging system were both prognostic for disease\u2010free interval. Incomplete histologic excision was associated with significantly increased rates of metastasis and tumour progression, and a shorter median survival time (MST). Cats that developed local recurrence also had a significantly shorter MST. The results of this study do not support the use of perioperative desmopressin to improve outcome when performing bilateral mastectomy for the treatment of mammary carcinoma in cats.<\/jats:p>","DOI":"10.1111\/vco.12636","type":"journal-article","created":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T18:17:07Z","timestamp":1593800227000},"page":"724-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of perioperative desmopressin in cats with mammary carcinoma treated with bilateral mastectomy"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-060X","authenticated-orcid":false,"given":"Christopher J.","family":"Wood","sequence":"first","affiliation":[{"name":"VCA Canada \u2010 Alta Vista Animal Hospital Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L.","family":"Chu","sequence":"additional","affiliation":[{"name":"VCA Canada \u2010 Alta Vista Animal Hospital Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6695-6273","authenticated-orcid":false,"given":"Laura E.","family":"Selmic","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Science, College of Veterinary Medicine The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp D.","family":"Mayhew","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine University of California\u2010Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Holt","sequence":"additional","affiliation":[{"name":"Section of Surgery, Matthew J. Ryan Veterinary Hospital, Department of Clinical Studies, School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Martano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Parma Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-983X","authenticated-orcid":false,"given":"Bernard","family":"S\u00e9guin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Flint Animal Cancer Center Colorado State University Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph Guelph Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Boston","sequence":"additional","affiliation":[{"name":"VCA Canada \u2010 404 Veterinary Emergency and Referral Newmarket Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassie","family":"Lux","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Tennessee Knoxville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-7157","authenticated-orcid":false,"given":"Julius M.","family":"Liptak","sequence":"additional","affiliation":[{"name":"VCA Canada \u2010 Alta Vista Animal Hospital Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2005.tb02727.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.5326\/0420110"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"201","article-title":"Prognostic factors for feline mammary tumors","volume":"185","author":"MacEwen EG","year":"1984","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.252.11.1393"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9975(98)80049-2"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.10.030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.58.723"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(02)00042-5"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814528221"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0244.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00190.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488607781668891"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2007.06.015"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5509"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006291607871"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307183"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)92805-5"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.7.2515"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.7.2760.2760"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.10141"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2016.00119"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2019.00387"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80235-1"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200007000-00009"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1536"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan3464"},{"issue":"11","key":"e_1_2_8_28_1","first-page":"1393","article-title":"Association of surgical approach with complication rate, progression\u2010free survival time, and disease\u2010specific survival time in cats with mammary adenocarcinoma: 107 cases (1991\u20132014)","volume":"252","author":"De Maria R","year":"2005","journal-title":"J Am Vet Med Assoc"},{"issue":"5","key":"e_1_2_8_29_1","first-page":"825","article-title":"Feline breast carcinoma as a pathologic and therapeutic model for human breast cancer","volume":"8","author":"Hahn KA","year":"1994","journal-title":"In Vivo"},{"key":"e_1_2_8_30_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2460\/javma.1994.205.02.168","article-title":"Use of the vasopressin analogue desmopressin for polyuria and bleeding disorders","volume":"205","author":"Nichols TC","year":"1994","journal-title":"J Am Vet Med Assoc"},{"issue":"2","key":"e_1_2_8_31_1","first-page":"265","article-title":"The effects of desmopressin on hemostatic parameters in the normal dog","volume":"50","author":"Johnstone IB","year":"1986","journal-title":"Can J Vet Res"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1217-y"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30149-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1661038"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1980.tb02749.x"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198301063080102"},{"issue":"4","key":"e_1_2_8_37_1","first-page":"437","article-title":"A bleeding disorder (von Willebrand's disease) in a Himalayan cat","volume":"190","author":"French TW","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/vec.12185"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2014.03.001"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2004.09.009"},{"key":"e_1_2_8_41_1","volume-title":"MacEwen's Small Animal Clinical Oncology","author":"Vail DM","year":"2020"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb00229.x"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.5986"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2607"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-1-120"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814543198"},{"issue":"4","key":"e_1_2_8_47_1","first-page":"709","article-title":"Prognostic factors in feline mammary carcinoma","volume":"70","author":"Weijer K","year":"1983","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12748"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fvco.12636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12636","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T05:20:59Z","timestamp":1723180859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/vco.12636"],"URL":"https:\/\/doi.org\/10.1111\/vco.12636","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"assertion":[{"value":"2020-05-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}