{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:25:53Z","timestamp":1793255153513,"version":"4.5.0"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tumour stage has been demonstrated to have prognostic significance in canine oral malignant melanoma (OMM). Various evaluation techniques of positron emission tomography\/computed tomography (PET\/CT) have been reported for staging of head\u2010and\u2010neck tumours in people, but canine\u2010specific data are limited, and reports for CT accuracy have been variable. In this prospective study, the head\/neck of client\u2010owned dogs with cytologically or histologically diagnosed OMM were imaged with<jats:sup>18<\/jats:sup>Fluorine\u2010fluorodeoxyglucose (<jats:sup>18<\/jats:sup>F\u2010FDG) PET\/ CT. Bilateral mandibular lymphadenectomy was performed for histopathologic assessment. Two evaluation techniques for CT and PET were applied by four independent observers. CT evaluation utilized both a standardized grading scheme and a subjective clinical interpretation. PET evaluation was first performed solely on<jats:sup>18<\/jats:sup>F\u2010FDG\u2010uptake in lymph nodes compared to background on a truncated scan excluding the oral cavity. Subsequently, the entire head\/neck scan and standardized uptake value (SUV) measurements were available. Receiver operating characteristic analysis was performed with histopathology as gold standard. Twelve dogs completed the study and metastatic OMM was identified in six mandibular lymph nodes from five dogs. Of the CT\u2010interpretation techniques, use of clinical grading performed best (sensitivity\u00a0=\u00a083% and specificity\u00a0=\u00a094%). Both PET techniques resulted in 100% sensitivity, but primary tumour site evaluation and use of SUV increased specificity from 78% to 94%. The SUVmax cut\u2010point, 3.3, led to 100% sensitivity and 83% specificity. In this population of dogs, PET appeared to be highly sensitive but at risk of being less specific without use of appropriate parameters and thresholds.<\/jats:p>","DOI":"10.1111\/vco.12651","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T12:40:13Z","timestamp":1600346413000},"page":"463-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Evaluation of accuracy for<sup>18<\/sup>F\u2010FDG positron emission tomography and computed tomography for detection of lymph node metastasis in canine oral malignant melanoma"],"prefix":"10.1111","volume":"19","author":[{"given":"Jennifer L.","family":"Willcox","sequence":"first","affiliation":[{"name":"Department of Veterinary Surgery and Radiology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Spriet","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Radiology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L.","family":"Zwingenberger","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Radiology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Radiology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna H.","family":"Burton","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Radiology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"Skorupski","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Radiology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Radiology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena K.","family":"Affolter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Woolard","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Beylin","sequence":"additional","affiliation":[{"name":"Brain Biosciences, Inc Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Giuffrida","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgery and Radiology University of California, Davis Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"issue":"11","key":"e_1_2_10_2_1","first-page":"1202","article-title":"Epidemiologic analysis of oral and pharyngeal cancer in dogs, cats, horses, and cattle","volume":"169","author":"Dorn CR","year":"1976","journal-title":"J am Vet Med Assoc"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1992.tb01707.x"},{"issue":"7","key":"e_1_2_10_4_1","first-page":"242","article-title":"Oropharyngeal tumors of dogs\u2013a clinical study of 79 cases","volume":"111","author":"Horsting N","year":"1998","journal-title":"Berl Munch Tierarztl Wochenschr"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12624"},{"key":"e_1_2_10_6_1","first-page":"39","article-title":"Survival analysis of oral melanoma in dogs","volume":"23","author":"Kudnig STEN","year":"2003","journal-title":"Vet Cancer Soc Proc."},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.37-6-597"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12229"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.254.8.938"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357908609017520"},{"issue":"6","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2460\/javma.1997.210.06.785","article-title":"Analysis of prognostic factors and patterns of failure in dogs with periodontal tumors treated with megavoltage irradiation","volume":"210","author":"Theon AP","year":"1997","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2003.tb00468.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.245.11.1266"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.245.4.401"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.247.10.1146"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2003.222.1234"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985817698209"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01675.x"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12415"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"issue":"7","key":"e_1_2_10_21_1","first-page":"670","article-title":"A fluorinated glucose analog, 2\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose (F\u201018): nontoxic tracer for rapid tumor detection","volume":"21","author":"Som P","year":"1980","journal-title":"J Nucl Med"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.10.002"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199307000-00012"},{"issue":"7","key":"e_1_2_10_24_1","first-page":"41","article-title":"Use of positron emission tomography in oncology","volume":"7","author":"Glaspy JA","year":"1993","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0969-8051(94)90045-0"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.021"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-8-70"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2337-4"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.02.008"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.5634"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmir.2019.05.001"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-019-02252-2"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172651"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12047"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.15453"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2012.01925.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-007-0097-9"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.08.008"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.08.1431"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-019-01413-7"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002590050293"},{"issue":"3","key":"e_1_2_10_42_1","first-page":"836","article-title":"False positive PET scan deserves attention","volume":"19","author":"Akgul AG","year":"2014","journal-title":"J BUON"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01520.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01757.x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2011.10.021"},{"key":"e_1_2_10_46_1","unstructured":"TNM classification of tumours in domestic animals.World Health Organization; Accessed November 11 2019."},{"issue":"4","key":"e_1_2_10_47_1","first-page":"417","article-title":"Common terminology criteria for adverse events (VCOG\u2010CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.1","volume":"14","author":"Veterinary cooperative oncology group","year":"2011","journal-title":"Vet Comp Oncol"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2003.tb00488.x"},{"key":"e_1_2_10_49_1","volume-title":"High Resolution PET Scanner Optimized for Neurological Imaging","author":"Beylin D","year":"2013"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2010.01727.x"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000097"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2015-0018"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.08.017"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12562"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1536-1632(02)00002-1"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-006-0065-0"},{"issue":"10","key":"e_1_2_10_58_1","first-page":"1836","article-title":"SUV: standard uptake or silly useless value?","volume":"36","author":"Keyes JW","year":"1995","journal-title":"J Nucl Med"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn125"},{"issue":"17","key":"e_1_2_10_60_1","first-page":"1309","article-title":"Diagnostic value of (18)F\u2010fluorodeoxyglucose positron emission tomography\/ computed tomography for N\u2010and M\u2010staging of malignant melanoma","volume":"94","author":"Gu H","year":"2014","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-011-1664-1"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2014.01.002"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-017-3674-8"},{"key":"e_1_2_10_64_1","first-page":"Cd012806","article-title":"Ultrasound, CT, MRI, or PET\u2010CT for staging and re\u2010staging of adults with cutaneous melanoma","volume":"7","author":"Dinnes J","year":"2019","journal-title":"Cochrane Database Syst Rev."},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.17159\/2078-5151\/2019\/v57n3a2832"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.113.133801"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001205"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016142043"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12032"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12154"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12651","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12651","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T01:31:17Z","timestamp":1723599077000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,17]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/vco.12651"],"URL":"https:\/\/doi.org\/10.1111\/vco.12651","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,17]]},"assertion":[{"value":"2020-06-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}