{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:36:44Z","timestamp":1785393404340,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In humans B\u2010symptoms refer to systemic symptoms of lymphoma such as fever, weight loss, and night sweats and influence the prognosis of patients. In canine lymphoma, substage B is used to describe any clinical sign observed. Aim of the retrospective study was to compare the prognostic value of substage B with B\u2010symptoms to predict treatment response and survival in canine nodal diffuse large B\u2010cell lymphoma. Affected dogs treated with CHOP chemotherapy between 2008 and 2019 were included. B\u2010symptoms were defined by weight loss greater than 10% of normal weight, fever and the occurrence of unexplained resting tachypnoea substituted human night sweats. Substage B was defined as any symptoms but lymphadenopathy. Fifty\u2010five cases were included. B\u2010symptoms were present in 20\/55 (36%) and substage B in 40\/55 (74%) patients. No significant associations between B\u2010symptoms or substage B and weight, sex, breed, WHO stage and lymphoma grade were found. Treatment response was negatively associated with both substage B (<jats:italic>P = .02<\/jats:italic>) and B\u2010symptoms (<jats:italic>P = .001<\/jats:italic>). B\u2010symptoms significantly decreased progression free survival (PFS) (95 vs 330\u2009days, <jats:italic>P = .001<\/jats:italic>) and lymphoma specific survival (LSS) (160 vs 462\u2009days, <jats:italic>P = .001<\/jats:italic>). Data showed that B\u2010symptoms might be a more reliable prognostic indicator than substage B in canine nodal diffuse large B\u2010cell lymphoma. Prospective studies assessing B\u2010symptoms in a larger cohort of patients and in other common lymphoma types are warranted. The abstract was presented at the fourth meeting of the European Canine Lymphoma Network Group in Lugano, 22 June 2019 and published in the proceeding of the meeting on the page 26.<\/jats:p>","DOI":"10.1111\/vco.12661","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T12:07:09Z","timestamp":1604318829000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Are B\u2010symptoms more reliable prognostic indicators than substage in canine nodal diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-2923","authenticated-orcid":false,"given":"Ond\u0159ej","family":"\u0160kor","sequence":"first","affiliation":[{"name":"Department of Companion Animals and Horses Vetmeduni  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-489X","authenticated-orcid":false,"given":"Ludmila","family":"Bicanov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Companion Animals and Horses Vetmeduni  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-5832","authenticated-orcid":false,"given":"Birgitt","family":"Wolfesberger","sequence":"additional","affiliation":[{"name":"Department of Companion Animals and Horses Vetmeduni  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2671-715X","authenticated-orcid":false,"given":"Andrea","family":"Fuchs\u2010Baumgartinger","sequence":"additional","affiliation":[{"name":"Department for Pathobiology Vetmeduni  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9080-0164","authenticated-orcid":false,"given":"Barbara","family":"Ruetgen","sequence":"additional","affiliation":[{"name":"Department for Pathobiology Vetmeduni  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"\u0160t\u011brbov\u00e1","sequence":"additional","affiliation":[{"name":"Small Animal Clinic University of Veterinary and Pharmaceutical Sciences  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Schwendenwein","sequence":"additional","affiliation":[{"name":"Department for Pathobiology Vetmeduni  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-3973","authenticated-orcid":false,"given":"Miriam","family":"Kleiter","sequence":"additional","affiliation":[{"name":"Department of Companion Animals and Horses Vetmeduni  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2016.00077"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.207027"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2283"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2000.tb02224.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304083281404"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011795"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.07.009"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1993.tb01021.x"},{"key":"e_1_2_8_11_1","unstructured":"OwenLN World Health Organization.TNM Classification of Tumours in Domestic Animals\/edited by LN Owen.Geneva: World Health Organization 1980; 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