{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:07:43Z","timestamp":1790251663988,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Published radiotherapy results for suspected heart\u2010based tumours in dogs are limited. In this retrospective longitudinal study (3\/2014\u20102019), eight dogs with either clinical signs attributable to a heart\u2010base mass (6), or asymptomatic with a progressively larger mass on echocardiogram (2), received conventional fractionated radiotherapy (CFRT) or stereotactic body radiotherapy (SBRT). Clinical findings in symptomatic cases included one or more of the following: retching\/coughing (4), exercise intolerance (2), collapse (1), pericardial effusion (2), rare ventricular premature contractions (2), abdominal effusion (1), or respiratory distress due to chylothorax (1). CFRT cases received 50 Gray (Gy) in 20 fractions and SBRT cases received 30\u2009Gy in 5 or 24\u2009Gy in three fractions. Two dogs received chemotherapy post\u2010radiation. At analysis, 7\/8 dogs were deceased and one was alive 684\u2009days post\u2010treatment. The estimated median overall survival (MOS) from first treatment was 785\u2009days (95% CI 114\u2010868\u2009days, [range 114\u20101492\u2009days]). Five dogs received CFRT (MOS 817\u2009days; (95% CI 155\u2009days\u2010not reached [range 155\u20101492\u2009days])). Three dogs received SBRT with one alive at analysis (MOS 414\u2009days, (95% CI, 114\u2009days\u2010not reached [range 114\u2010414\u2009days])). No statistically significant difference was found between survival for CFRT and SBRT. Of the symptomatic patients, 5\/6 showed improvement. Mass size reduced in 4\/5 cases receiving follow\u2010up ultrasounds. Possible complications included asymptomatic radiation pneumonitis (4), atrial tachycardia\/premature beats (4) and pericardial effusion with heart failure coincident with tumour progression (1). This study provides preliminary evidence that radiotherapy may impact clinically relevant or progressively enlarging heart\u2010base masses.<\/jats:p>","DOI":"10.1111\/vco.12662","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T12:06:17Z","timestamp":1604318777000},"page":"191-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term outcomes with conventional fractionated and stereotactic radiotherapy for suspected heart\u2010base tumours in dogs"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9700-1290","authenticated-orcid":false,"given":"Katherine S.","family":"Hansen","sequence":"first","affiliation":[{"name":"Department of Surgical and Radiological Sciences University of California Davis, School of Veterinary Medicine  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain 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