{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:26:15Z","timestamp":1788866775043,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T00:00:00Z","timestamp":1610496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Canine appendicular osteosarcoma is commonly treated with limb amputation; however, limb\u2010sparing options are frequently desired or necessary for a subset of patients. We evaluated 123 patients and 130 sites treated with stereotactic body radiation therapy (SBRT). Eighty\u2010two out of 98 dogs (84%) had maximum lameness improvement at a median of 3\u2009weeks for a median of 6\u2009months duration. Histopathologic evaluation of available samples from amputation or necropsy revealed &gt;80% tumor necrosis in 50% of limbs consistent with local disease control. Of evaluable patients, 41% fractured and 21% pursued an amputation after treatment. Fine needle aspirate (n\u00a0=\u00a052) and needle core biopsy (n\u00a0=\u00a028) did not result in increased fracture risk compared to those without tumor sampling (n\u00a0=\u00a050). Median survival time (MST) was 233\u2009days and time to first event was 143\u2009days. Gross tumor volume and planned target volume were significantly inversely associated with survival and tumor location was significantly associated with survival. Dogs with salvage amputation had a significantly longer MST compared to those without (346 vs 202\u2009days;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.04). The presence of metastatic disease at the time of treatment in 15 dogs did not significantly impact survival time (200 vs 237\u2009days without metastasis;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a0.58). Skin side effects correlated significantly with dose with 33% of patients with acute grade 3 effects developing consequential late grade 3 effects. While SBRT improves lameness in most patients, further investigation is needed to identify candidates with minimal early fracture risk prior to initiating therapy.\n                  <\/jats:p>","DOI":"10.1111\/vco.12674","type":"journal-article","created":{"date-parts":[[2021,1,6]],"date-time":"2021-01-06T18:16:07Z","timestamp":1609956967000},"page":"284-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Outcome and prognosis for canine appendicular osteosarcoma treated with stereotactic body radiation therapy in 123 dogs"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4861","authenticated-orcid":false,"given":"Tiffany Wormhoudt","family":"Martin","sequence":"first","affiliation":[{"name":"Department of Environment and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado 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