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Pre\u2010treatment leukocyte counts and ratios play a recognized prognostic role in several types of malignancies, but no information is available regarding canine oral malignant melanoma (COMM). The purpose of this explorative retrospective study was to investigate the prognostic impact of pre\u2010treatment neutrophil to lymphocyte (NLR) and lymphocyte to monocyte (LMR) ratios in dogs with oral malignant melanoma that underwent surgical resection and immunotherapy with adjuvant CSPG4\u2010antigen electrovaccination. Thirty\u2010nine dogs with histologically confirmed oral melanoma and with available pre\u2010treatment haematological analyses, performed at maximum 60\u2009days before the first treatment, were retrospectively enrolled. Statistical analysis was performed to explore possible correlations among NLR and LMR with age, clinical stage, tumour pigmentation, tumour size, nuclear atypia, mitotic index, Ki67, CSPG4 expression, ulceration, bone invasion and excision margins status. The impact of NLR and LMR on overall survival time (OST) was explored among various ratio cut off and across different time points with Kaplan\u2010Meier method. No significant relationship was identified between leukocytes ratios and histological parameters, CSPG4 expression, excision margin status, age, tumour size and clinical stage. NLR and LMR did not display a prognostic impact on the survival time of the entire population. Pre\u2010treatment leukocyte ratios may not represent a useful prognostic factor in dogs with oral melanoma, especially in absence of distant metastatic disease.<\/jats:p>","DOI":"10.1111\/vco.12679","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T19:06:12Z","timestamp":1610737572000},"page":"353-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Evaluation of prognostic impact of pre\u2010treatment neutrophil to lymphocyte and lymphocyte to monocyte ratios in dogs with oral malignant melanoma treated with surgery and adjuvant<scp>CSPG4<\/scp>\u2010antigen electrovaccination: an\u00a0explorative\u00a0study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2850-6794","authenticated-orcid":false,"given":"Mariateresa","family":"Camerino","sequence":"first","affiliation":[{"name":"Department of Veterinary Sciences University of Torino 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