{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:16:24Z","timestamp":1781000184623,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,9,16]],"date-time":"2021-09-16T00:00:00Z","timestamp":1631750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["#201806760044"],"award-info":[{"award-number":["#201806760044"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thyroid carcinomas (TCs) originating from follicular cells of the thyroid gland occur in both humans and dogs, and they have highly similar histomorphologic patterns. In dogs, TCs have not been extensively investigated, especially concerning the familial origin of TCs. Here, we report familial thyroid follicular cell carcinomas (FCCs) confirmed by histology in 54 Dutch origin German longhaired pointers. From the pedigree, 45 of 54 histopathologically confirmed cases are closely related to a pair of first\u2010half cousins in the past, indicating a familial disease. In addition, genetics contributed more to the thyroid FCC than other factors by an estimated heritability of 0.62 based on pedigree. The age of diagnosis ranged between 4.5 and 13.5\u2009years, and 76% of cases were diagnosed before 10\u2009years of age, implying an early onset of disease. We observed a significant higher pedigree\u2010based inbreeding coefficient in the affected dogs (mean\n                    <jats:italic>F<\/jats:italic>\n                    , 0.23) compared to unaffected dogs (mean\n                    <jats:italic>F<\/jats:italic>\n                    , 0.14), suggesting the contribution of inbreeding to tumour development. The unique occurrence of familial thyroid FCC in this dog population and the large number of affected dogs make this population an important model to identify the genetic basis of familial thyroid FCC in this breed and may contribute to the research into pathogenesis, prevention and treatment in humans.\n                  <\/jats:p>","DOI":"10.1111\/vco.12769","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T10:17:43Z","timestamp":1630405063000},"page":"227-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Familial follicular cell thyroid carcinomas in a large number of Dutch German longhaired pointers"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7521-110X","authenticated-orcid":false,"given":"Yun","family":"Yu","sequence":"first","affiliation":[{"name":"Animal Breeding and Genomics Wageningen University &amp; Research  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Krupa","sequence":"additional","affiliation":[{"name":"AniCura Dierenziekenhuis Zeeuws\u2010Vlaanderen  Terneuzen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebekah I.","family":"Keesler","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Health Sciences, Division of Pathology, Faculty of Veterinary Medicine Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy C. M.","family":"Grinwis","sequence":"additional","affiliation":[{"name":"Department of Biomolecular Health Sciences, Division of Pathology, Faculty of Veterinary Medicine Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariska","family":"de Ruijsscher","sequence":"additional","affiliation":[{"name":"AniCura Dierenziekenhuis Zeeuws\u2010Vlaanderen  Terneuzen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"de Vos","sequence":"additional","affiliation":[{"name":"AniCura Dierenziekenhuis Zeeuws\u2010Vlaanderen  Terneuzen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martien A. M.","family":"Groenen","sequence":"additional","affiliation":[{"name":"Animal Breeding and Genomics Wageningen University &amp; Research  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P. M. A.","family":"Crooijmans","sequence":"additional","affiliation":[{"name":"Animal Breeding and Genomics Wageningen University &amp; Research  Wageningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0231"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2002.tb00066.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5877(03)00010-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40575-018-0066-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2007.03.008"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2007.03.007"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/0460249"},{"key":"e_1_2_9_9_1","first-page":"25","volume-title":"Histological Classification of Tumors of the Endocrine System of Domestic Animals","author":"Kiupel M","year":"2008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0155"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0537"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.147"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw013"},{"issue":"5","key":"e_1_2_9_15_1","first-page":"1173","article-title":"A dog pedigree with familial medullary thyroid cancer","volume":"29","author":"Lee J\u2010J","year":"2006","journal-title":"Int J Oncol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363105"},{"key":"e_1_2_9_17_1","unstructured":"SargolzaeiM IwaisakiH ColleauJJ.CFC: a tool for monitoring genetic diversity: Proceedings of the 8th World Congress on Genetics Applied to Livestock Production. 2006:27\u201328."},{"key":"e_1_2_9_18_1","unstructured":"GilmourAR Gogel BJ Cullis BR Welham SJ Thompson R.ASReml User Guide Release 4.1 Structural Specification H.VSN International Ltd. 2015."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9312-z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-017-0048-0"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092178"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12711-019-0497-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2017.2589"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jhered\/esp039"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10332"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0906-1065b"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2011.02.004"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12769","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12769","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:09:23Z","timestamp":1692835763000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,16]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/vco.12769"],"URL":"https:\/\/doi.org\/10.1111\/vco.12769","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.03.12.434920","asserted-by":"object"}]},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,16]]},"assertion":[{"value":"2021-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}