{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:54Z","timestamp":1787016114482,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,19]],"date-time":"2021-12-19T00:00:00Z","timestamp":1639872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary pulmonary histiocytic sarcoma (PHS) is a rare form of dendritic cell or macrophage neoplasia originating within the pulmonary parenchyma. There is limited literature describing prognosis in dogs with PHS receiving curative\u2010intent treatment consisting of surgical excision and adjuvant chemotherapy. The primary objective of this study was to report outcomes in dogs with localized PHS treated with standardized local and systemic therapy. A secondary objective was to identify prognostic factors in this population. A multi\u2010institutional retrospective study was performed and medical records including all surgical and histopathologic reports were retrospectively reviewed. For inclusion, dogs were required to have confirmed localized PHS and they must have undergone curative\u2010intent surgery with resection of all gross primary tumour and enlarged tracheobronchial lymph nodes; additionally, they must have received curative\u2010intent treatment with adjuvant single\u2010agent CCNU chemotherapy. Twenty\u2010seven dogs from six veterinary teaching hospitals and five private practices treated from 2008\u20132019 were included. The overall median survival time was 432\u2009days. Higher CCNU dose was demonstrated to have a negative impact on survival on univariate, but not multivariable, analysis. Factors that were not found to be associated with survival on univariate analysis included body weight, breed, clinical signs at the time of diagnosis, hypoalbuminaemia, tumour size, lung lobe affected, lymph node metastasis, surgical margins and CCNU dose reductions. This study supports a favourable prognosis for dogs diagnosed with localized PHS treated with curative\u2010intent surgery in addition to adjuvant CCNU chemotherapy and suggests that multimodal treatment may be advisable to attempt to prolong survival.<\/jats:p>","DOI":"10.1111\/vco.12791","type":"journal-article","created":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T10:40:58Z","timestamp":1638960058000},"page":"458-464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Outcome in dogs with curative\u2010intent treatment of localized primary pulmonary histiocytic sarcoma"],"prefix":"10.1111","volume":"20","author":[{"given":"Caroline A.","family":"Murray","sequence":"first","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2107-6226","authenticated-orcid":false,"given":"Jennifer L.","family":"Willcox","sequence":"additional","affiliation":[{"name":"Department of Veterinary Surgical and Radiological Sciences University of California Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4771-7829","authenticated-orcid":false,"given":"Carlos H.","family":"De Mello Souza","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, College of Veterinary Medicine University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Husbands","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Clinical Sciences Ohio State University Columbus Ohio 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of Wisconsin Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Richardson","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Ontario Veterinary College University of Guelph Ontario USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chamisa L.","family":"Herrera","sequence":"additional","affiliation":[{"name":"Boundary Bay Veterinary Specialty Hospital Langley British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Krick","sequence":"additional","affiliation":[{"name":"Mount Laurel Animal Hospital Mount Laurel New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McMillan","sequence":"additional","affiliation":[{"name":"Veterinary Emergency\u2009+\u2009Referral Center of Hawaii Honolulu Hawaii 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