{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:27:16Z","timestamp":1771302436430,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canine thymomas are routinely treated with radiotherapy (RT). In this study, we investigate the response and toxicity of canine thymoma treated with intensity\u2010modulated stereotactic body radiation therapy (SBRT) relative to dogs treated with hypofractionated non\u2010modulated radiation therapy (NMRT). A retrospective study was performed of dogs with thymoma treated with RT (total: <jats:italic>n<\/jats:italic>\u00a0=\u00a015; SBRT: <jats:italic>n<\/jats:italic>\u00a0=\u00a08, NMRT: <jats:italic>n<\/jats:italic>\u00a0=\u00a07). Tumour response was evaluated in six dogs (40%); following SBRT, three dogs (100%) experienced stable disease (SD); following NMRT, one dog (33%) had a PR, and two dogs (67%) had SD. Median PFS was 116\u2009days (range 66\u2013727\u2009days) for the SBRT group and 134\u2009days (range 10\u2013405\u2009days) for the NMRT group. The MST for the SBRT group was 250\u2009days (range 1\u2013727\u2009days) and 155\u2009days (range 10\u2013405\u2009days) for NMRT. Median disease\u2010specific survival was 250\u2009days (range 1\u2013727\u2009days) for the SBRT group and 169\u2009days (range 20\u2013405\u2009days) for the NMRT group. No significant differences in survival data were found between the treatment groups, however the results from the small number of dogs analysed are likely underpowered for statistical comparisons. Reported acute and late side effects were limited to the lungs and heart and were statistically significantly more common in the NMRT (71%) compared to the SBRT group (25%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.04). We suggest similar treatment efficacy may be provided for canine thymoma treated with either approach, but SBRT could provide the clinical benefit of reduced incidence of radiation\u2010induced toxicity and completion of RT in a shorter time frame.<\/jats:p>","DOI":"10.1111\/vco.12797","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T14:06:04Z","timestamp":1640181964000},"page":"491-501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of dogs with thymoma treated with intensity modulated stereotactic body radiation therapy or non\u2010modulated hypofractionated radiation therapy"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-0046","authenticated-orcid":false,"given":"Erin","family":"Trageser","sequence":"first","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4861","authenticated-orcid":false,"given":"Tiffany","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Hoaglund","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Del","family":"Leary","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"LaRue","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-4502","authenticated-orcid":false,"given":"Mary\u2010Keara","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado 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