{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T14:53:48Z","timestamp":1786719228896,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011073","name":"VetAgro Sup","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011073","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human grading system is currently applied to canine meningioma, although it has not been validated in dogs. The present study focused on standardising the human grading system applied to canine meningioma. Four veterinary neuropathologists graded 186 canine meningiomas as follows: Grade I tumour, with &lt;4\u00a0mitoses\/2.37\u2009mm<jats:sup>2<\/jats:sup>; Grade II tumour, with \u22654\u00a0mitoses\/2.37\u2009mm<jats:sup>2<\/jats:sup>, brain invasion or at least three of the following criteria: sheeting architecture, hypercellularity, small cells, macronucleoli, necrosis; Grade III tumour, with \u226520\u2009mitoses\/2.37\u2009mm<jats:sup>2<\/jats:sup> or anaplasia. Slides with grading disagreement were reviewed to define a consensus diagnosis and to assess reproducible criteria. Concordance between histologic grade and the consensus diagnosis, as well as intra\u2010 and inter\u2010observer agreements for each criterion, were statistically analysed. Concordance between histologic grade and consensus diagnosis ranged from 59% to 100%, with lower concordance for Grade I and II tumours. The lowest inter\u2010observer agreement was recorded for macronucleoli, small cells, hypercellularity and sheeting architecture. Tumour invasion and necrosis displayed fair agreement, while moderate agreement was reached for mitotic grade and anaplasia. The following recommendations were issued to improve the reproducibility of canine meningioma grading: (1) Assess mitotic grade in consecutive HPFs within the most mitotically active area; (2) Define invasion as neoplastic protrusions within central nervous tissue without pial lining; (3) Report spontaneous necrosis; (4) Report prominent nucleoli when visible at \u00d7100; (5) Report pattern loss when visible at \u00d7100 in &gt;50% of the tumour; (6) Report necrosis, small cells, hypercellularity and macronucleoli, even when focal; (7) Report anaplasia if multifocal.<\/jats:p>","DOI":"10.1111\/vco.12802","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T10:34:03Z","timestamp":1642934043000},"page":"509-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Standardisation of canine meningioma grading: Inter\u2010observer agreement and recommendations for reproducible histopathologic criteria"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-6879","authenticated-orcid":false,"given":"Sara","family":"Belluco","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, ICE UPSP 2016.A104, Axe Canc\u00e9rologie, Marcy l'Etoile  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Marano","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cL. Sacco\u201d University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Baiker","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine and Science University of Nottingham, Sutton Bonington Campus  Sutton Bonington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Beineke","sequence":"additional","affiliation":[{"name":"Stiftung Tier\u00e4rztliche Hochschule Hannover Institut f\u00fcr Pathologie  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Oevermann","sequence":"additional","affiliation":[{"name":"Division of Neurological Sciences Vetsuisse Faculty, University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Seehusen","sequence":"additional","affiliation":[{"name":"FTA Pathologie Universit\u00e4t Z\u00fcrich, Vetsuisse\u2010Fakult\u00e4t, Institut f\u00fcr Veterin\u00e4rpathologie  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Boracchi","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Clinical Sciences \u201cL. Sacco\u201d University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marti","family":"Pumarola","sequence":"additional","affiliation":[{"name":"Department Medicina i Cirurgia, Animals Facultat de Veterin\u00e0ria, Campus UAB  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Mandara","sequence":"additional","affiliation":[{"name":"Laboratorio di Neuropatologia, Dipartimento di Medicina Veterinaria Universit\u00e0 degli Studi di Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02913.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12136"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.1988.tb02796.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2008.0106.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748\u20105827.2011.01131.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12385"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1892\/0891\u20106640(2006)20[663:vegfei]2.0.co;2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4314\/ovj.v7i4.14"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2011.10.008"},{"key":"e_1_2_8_11_1","volume-title":"Histological Classification of Tumors of the Nervous System of Domestic Animals","author":"Koestner A.","year":"1999"},{"key":"e_1_2_8_12_1","first-page":"834","volume-title":"Tumors in Domestic Animals","author":"Higgins RJ","year":"2017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.08\u2010VP\u20100185\u2010M\u2010FL"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01151"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2008.00042.x"},{"key":"e_1_2_8_16_1","volume-title":"Veterinary Neuropathology: Essentials of Theory and Practice","author":"Vandevelde M","year":"2012"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2011.10.019"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov247"},{"key":"e_1_2_8_19_1","unstructured":"R Foundation for Statistical Computing Vienna Austria.R: The R Project for Statistical Computing. Accessed June 10 2021.https:\/\/www.r-project.org\/"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104614\u20100562\u20107"},{"key":"e_1_2_8_21_1","unstructured":"GwetKL.irrCAC: computing chance\u2010corrected agreement coefficients (CAC). Accessed June 10 2021.https:\/\/CRAN.R-project.org\/package=irrCAC"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010540\u201078246\u20109_38"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20103\u2010540\u201078246\u20109"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"issue":"3","key":"e_1_2_8_25_1","first-page":"231","article-title":"The histopathological spectrum of human meningiomas","volume":"5","author":"Backer\u2010Gr\u00f8ndahl T","year":"2012","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23801"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985820980049"},{"key":"e_1_2_8_28_1","volume-title":"WHO Classification of Tumours Editorial Board. Central Nervous System Tumours [Internet]","author":"Sahm F","year":"2021"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815593349"},{"key":"e_1_2_8_30_1","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Louis DN","year":"2016"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060\u2010010\u20100343\u20101"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox071"},{"key":"e_1_2_8_33_1","volume-title":"Practical Surgical Neuropathology a Diagnostic Approach","author":"Arie Perry DJB","year":"2018"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12700"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2020.10.024"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/03009858211040476"}],"updated-by":[{"DOI":"10.1111\/vco.12953","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000}}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T16:30:43Z","timestamp":1692808243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,3]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/vco.12802"],"URL":"https:\/\/doi.org\/10.1111\/vco.12802","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1111\/vco.12953","asserted-by":"object"}]},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,3]]},"assertion":[{"value":"2021-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}