{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:49:53Z","timestamp":1786787393576,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In canine cutaneous mast cell tumours (cMCTs), histologic grade and clinical stage are the most important prognostic factors, with high\u2010grade tumours and metastatic lymph nodes (LNs) significantly influencing the evolution of disease. However, it is uncertain whether histologic grade and clinical stage should be given equal weighting value in patient prognostication and management. Dogs with low\u2010 and high\u2010grade cMCTs and at least one overtly metastatic sentinel LN undergoing standardized treatment, consisting of surgical excision of the cMCT, lymphadenectomy and chemotherapy, were retrospectively included. The aim was to determine whether, at the same clinical stage, histologic grade retained prognostic relevance. Sixty dogs were included: 26 had a high\u2010grade cMCT tumour and 34 had a low\u2010grade cMCT. Median follow\u2010up was 367\u2009days (range, 187\u2013748) in the high\u2010grade group, and 1208\u2009days (range, 180\u20132576) in the low\u2010grade group. Median time to progression was significantly shorter in the high\u2010grade group than in the low\u2010grade group (214\u2009days versus not reached; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), as well as tumour\u2010specific survival (545\u2009days versus not reached; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). On multivariable analysis, a high histologic grade and incomplete margins retained prognostic significance for both tumour progression and tumour\u2010specific death. In dogs with cMCT and at least one overtly metastatic LN undergoing multimodal treatment, histologic grade significantly correlated with outcome. Overall prognosis was not unfavourable, even in the high\u2010grade group, further supporting that a multimodal therapeutic approach, addressing primary tumour and sentinel LN, should be offered. Whether chemotherapy should be incorporated in the therapeutic planning of low\u2010grade cMCTs remains to be defined.<\/jats:p>","DOI":"10.1111\/vco.12806","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T14:40:14Z","timestamp":1645627214000},"page":"551-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Histologic grade has a higher\u2010weighted value than nodal status as predictor of outcome in dogs with cutaneous mast cell tumours and overtly metastatic sentinel lymph nodes"],"prefix":"10.1111","volume":"20","author":[{"given":"Dina","family":"Guerra","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-9326","authenticated-orcid":false,"given":"Eugenio","family":"Faroni","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7005-2736","authenticated-orcid":false,"given":"Silvia","family":"Sabattini","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Agnoli","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmit","family":"Chalfon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-0366","authenticated-orcid":false,"given":"Damiano","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Veterinaria Universit\u00e0 degli Studi di Milano  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2900-6989","authenticated-orcid":false,"given":"Sara","family":"Del Magno","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Cola","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Grieco","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Veterinaria Universit\u00e0 degli Studi di Milano  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"Laura","family":"Marconato","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810386469"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.246.7.765"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12425"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985814521638"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.07.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12565"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5557"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2007.00135.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12566"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-021-03043-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12995"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13483"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11082373"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2019.04.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2012.11.018"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12541"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12099.x"},{"key":"e_1_2_8_19_1","first-page":"933","article-title":"Recurrence rate, clinical outcome, and cellular proliferation indices as prognostic indicators after incomplete surgical excision of cutaneous grade II mast cell tumors: 28 dogs (1994\u20132002)","volume":"20","author":"S\u00e9guin B","year":"2006","journal-title":"J Vet Intern Med"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16264"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12021"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2009.00185.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12042"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12563"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198011000-00013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19911115)68:10<2142::AID-CNCR2820681010>3.0.CO;2-D"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01840834"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12306"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.142.5.456"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12675"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2019.04.003"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4906"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310460"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.11.004"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(98)00229-4"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2015.04.004"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02719381"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870501700305"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870501700606"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12806","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12806","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12806","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T22:29:43Z","timestamp":1692743383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/vco.12806"],"URL":"https:\/\/doi.org\/10.1111\/vco.12806","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]},"assertion":[{"value":"2021-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}