{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T22:58:51Z","timestamp":1771023531499,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canine splenic hemangiosarcoma (HSA) is an aggressive tumour of vascular endothelium that carries a grave prognosis following standard of care treatment with surgery and doxorubicin. A previous pilot study revealed potential anti\u2010tumour activity of I'm\u2010Yunity polysaccharopeptide (PSP) for canine HSA. The aim of this prospective study was to assess patient outcome when treated with PSP alone or in combination with doxorubicin post\u2010splenectomy compared to patients treated with surgery and doxorubicin that received a placebo in place of PSP. Dogs undergoing splenectomy for splenic HSA were eligible. Following splenectomy, owners were offered treatment with PSP alone or adjuvant doxorubicin chemotherapy (unblinded). Patients with owners that selected to proceed with doxorubicin chemotherapy were blindly randomized to receive placebo or PSP. Dogs were evaluated weekly for 15\u2009weeks, then scheduled for monthly visits until death. One hundred and one dogs were included in the final analysis: 51 PSP alone, 25 doxorubicin\/placebo, and 25 combination PSP\/doxorubicin. On multivariate analysis, dogs treated with single agent PSP, female dogs, decreased haematocrit at diagnosis, and stage III disease were negatively significantly associated with outcome; however, an interaction between treatment group and sex was documented. Gender\u2010specific outcomes revealed no significant difference in survival between treatment groups for male dogs, but female dogs treated with PSP alone had significantly reduced survival compared to females receiving doxorubicin\/placebo (HR 0.21; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). Anaemia (HR 5.28; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and stage III disease (HR 2.9; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.014) remained negatively associated with survival when controlling for sex and treatment group. The addition of PSP to doxorubicin post\u2010splenectomy did not improve survival in dogs with splenic HSA.<\/jats:p>","DOI":"10.1111\/vco.12823","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T15:20:57Z","timestamp":1650468057000},"page":"688-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of the anti\u2010tumour activity of <i>Coriolus versicolor<\/i> polysaccharopeptide (I'm\u2010Yunity) alone or in combination with doxorubicin for canine splenic hemangiosarcoma"],"prefix":"10.1111","volume":"20","author":[{"given":"Allison","family":"Gedney","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Salah","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Krick","sequence":"additional","affiliation":[{"name":"Mount Laurel Animal Hospital  Mount Laurel New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reenie","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Scavello","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9830-3151","authenticated-orcid":false,"given":"Matthew J.","family":"Atherton","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Biomedical Sciences, School of Veterinary Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"773","volume-title":"Withrow and MacEwen's Small Animal Clinical Oncology","author":"Mullin C","year":"2019"},{"issue":"6","key":"e_1_2_8_3_1","first-page":"706","article-title":"Epidemiologic, clinical, pathologic, and prognostic characteristics of splenic hemangiosarcoma and splenic hematoma in dogs: 217 cases (1985)","volume":"193","author":"Prymak C","year":"1988","journal-title":"J Am Vet Med Assoc"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"56","article-title":"Canine hemangiosarcoma: retrospective analysis of 104 cases","volume":"186","author":"Brown NO","year":"1985","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1997.tb00085.x"},{"issue":"4","key":"e_1_2_8_6_1","first-page":"250","article-title":"Splenic masses in dogs. 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