{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:00:10Z","timestamp":1789390810749,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013664","name":"College of Veterinary Medicine, Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005302","name":"University of Illinois at Urbana-Champaign","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005302","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Feline oral squamous cell carcinoma (FOSCC) is the most common oral tumour diagnosed in pet cats and carries a poor prognosis with &lt;10% one\u2010year survival despite multi\u2010modal therapies. Tumours of the mandible or maxilla are frequently osteo\u2010invasive and pain can result from osteolysis. Zoledronate is a bisphosphonate that inhibits osteoclasts and reduces bone resorption. Radiation therapy (RT) is used to treat FOSCC due to anti\u2010cancer activity and ability to improve quality of life. We hypothesized RT can be safely combined with zoledronate, and that this combinatory therapy would be efficacious, well tolerated, and result in decreased bone resorption in cats with FOSCC. SCCF1 cell line was treated with zoledronate before, concurrently, or after RT, and clonogenic assays were performed to determine if an optimal dosing schedule would be identified. Nine cats with osteoinvasive FOSCC were recruited for treatment with 4 weekly doses of 8\u00a0Gy RT combined with zoledronate administered at the first and fourth treatments. Serial CT scans were performed to assess tumour response. Safety and tolerability were monitored with hematologic and biochemical parameters, and acute radiation effects were characterized. Serum c\u2010telopeptide (CTx) and relative bone mineral density (rBMD) by dual \u2010energy X\u2010ray absorptiometry (DEXA) quantified bone resorption. In vitro studies showed no clear benefit to timing of zoledronate with RT, therefore all zoledronate was administered concurrently with RT in FOSCC patients. Based on tumour volume, 4\/9 (44.4%) cats achieved partial remission, 4\/9 (44.4%) stable disease and 1\/9 (11.1%) had progressive disease. The combinatory therapy was well\u2010tolerated based on biochemical measurements, and all patients experienced decreased serum CTx. Combining RT with zoledronate in tumour\u2010bearing cats is safe, well\u2010tolerated, results in a partial remission rate of up to 44%, and decreases serum CTx, a marker of bone resorption.<\/jats:p>","DOI":"10.1111\/vco.12830","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T14:06:43Z","timestamp":1652450803000},"page":"788-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Combining radiation therapy with zoledronate for the treatment of osteo\u2010invasive feline oral squamous cell carcinoma"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2576-3771","authenticated-orcid":false,"given":"Alycen P.","family":"Lundberg","sequence":"first","affiliation":[{"name":"Veterinary Clinical Medicine University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Tran Hoang","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Medicine University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"},{"name":"Veterinary Health Center\u2010Wentzville University of Missouri\u2010Columbia  Wentzville Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Billhymer","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Medicine University of Illinois at Urbana\u2010Champaign  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-3618","authenticated-orcid":false,"given":"Kim A.","family":"Selting","sequence":"additional","affiliation":[{"name":"Veterinary Clinical Medicine University of Illinois at Urbana\u2010Champaign  Urbana Illinois 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