{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:21:14Z","timestamp":1787016074068,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Melanomas arising from the foot pad are a rare clinical entity in dogs. The biologic behaviour of foot pad malignant melanoma is not well understood, and these tumours are infrequently described. The objective of this study was to evaluate the clinical characteristics of primary canine foot pad melanoma in a larger cohort of patients. Eligible cases were solicited from the American College of Veterinary Internal Medicine (ACVIM) Oncology listserv for retrospective review. Included dogs had a cytologic and\/or histologic diagnosis of foot pad melanoma evaluated by a board\u2010certified clinical or anatomic pathologist. Dogs with cutaneous, oral, digital, subungual or interdigital melanomas were excluded. A total of 20 cases were included. Eleven dogs received various adjuvant therapies including chemotherapy, radiation therapy, and\/or the ONCEPT canine melanoma vaccine following surgery. At diagnosis, regional lymph node metastasis was observed in four dogs (20%). Seven dogs developed subsequent regional and\/or distant metastasis for an overall metastatic rate of 55%. The progression\u2010free interval (PFI) was 101\u2009days (range, 20\u2013960\u2009days). The median survival time (MST) was 240\u2009days (range, 25\u2013479\u2009days). For dogs receiving adjuvant therapy, the MST was 159\u2009days (range, 25\u2013387\u2009days). Canine foot pad melanoma is a rare neoplasm that can exhibit an aggressive behaviour.<\/jats:p>","DOI":"10.1111\/vco.12846","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T12:54:32Z","timestamp":1656593672000},"page":"854-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Multi\u2010institutional retrospective study of canine foot pad malignant melanomas: 20 cases"],"prefix":"10.1111","volume":"20","author":[{"given":"Mark D.","family":"Jeon","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Oregon State University Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0900-0851","authenticated-orcid":false,"given":"Haley J.","family":"Leeper","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Oregon State University Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1825-2161","authenticated-orcid":false,"given":"Matthew R.","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Veterinary and Clinical Sciences The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"McMillan","sequence":"additional","affiliation":[{"name":"Veterinary Emergency and Referral Center of Hawaii Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristram","family":"Bennett","sequence":"additional","affiliation":[{"name":"Flint Animal Cancer Center Colorado State University Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A.","family":"Murray","sequence":"additional","affiliation":[{"name":"William R. Pritchard Veterinary Medical Teaching Hospital University of California Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea D.","family":"Tripp","sequence":"additional","affiliation":[{"name":"Bridge Animal Referral Center Edmonds Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin M.","family":"Curran","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Oregon State University Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810390717"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.39-6-651"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.43-2-136"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870601800422"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.245.11.1266"},{"issue":"9","key":"e_1_2_9_7_1","first-page":"981","article-title":"Post\u2010surgical outcome and prognostic factors in canine malignant melanomas of the haired skin: 87 cases (2003\u20102015)","volume":"59","author":"Laver T","year":"2018","journal-title":"Can Vet J"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098587901600103"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.245.4.401"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.72.12.1631"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12613"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12860"},{"key":"e_1_2_9_13_1","first-page":"20","article-title":"Multiple distinct malignancies in dogs: 53 cases","volume":"46","author":"Rebhun RB","year":"2010","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90171-X"},{"issue":"5","key":"e_1_2_9_15_1","first-page":"598","article-title":"Surgical resection of solitary metastasis of malignant melanoma to the right atrium","volume":"37","author":"Onan B","year":"2010","journal-title":"Tex Heart Inst J"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12057"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-59496-7.00020-7"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2460\/javma.1995.207.06.0726","article-title":"Evaluation of dogs with digit masses: 117 cases (1981\u20131991)","volume":"207","author":"Marino DJ","year":"1995","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_19_1","first-page":"61","volume-title":"Miller's Anatomy of the Dog","author":"Al\u2010Bagdadi F","year":"2013"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738-081X(94)90217-8"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2011.03.005"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12885"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12846","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.12846","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12846","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T01:27:03Z","timestamp":1727486823000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12846"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,12]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/vco.12846"],"URL":"https:\/\/doi.org\/10.1111\/vco.12846","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,12]]},"assertion":[{"value":"2022-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}