{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:53:24Z","timestamp":1779335604226,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canine cutaneous mast cell tumours (cMCTs) of the pinna have been associated with an aggressive biological behaviour, although data remain scarce. The knowledge acquired over the past years on histologic gradings, and the value of lymph node (LN) staging, may help in better characterizing this anatomical presentation. The first aim was to describe the frequency, location, and histologic appearance of LN metastases in cMCT of the pinna. A second aim was to evaluate prognosis. Medical records of dogs with cMCT of the pinna, that underwent tumour and sentinel (SLN) or regional LN (RLN) excision, were reviewed. The influence of potential prognostic variables on time to progression (TTP) and tumour\u2010specific survival (TSS) was investigated. Thirty\u2010nine dogs were included: 19 (48.7%) had Kiupel high\u2010grade (K\u2010HG) and 20 (51.3%) had low\u2010grade (K\u2010LG) MCTs. Eighteen (46.1%) dogs underwent SLN mapping: the superficial cervical LN was at least one of SLN in 17 (94.4%) cases. Twenty\u2010two (56.4%) dogs had LN metastases; the superficial cervical LN was always involved. On multivariable analysis, only K\u2010HG was associated with increased risk of progression (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.043) and tumour\u2010related death (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.021). Median TTP and TSS were 270 and 370\u2009days in K\u2010HG, respectively; these were not reached in dogs with K\u2010LG tumours (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). cMCTs of the pinna are often K\u2010HG and are also associated with a higher frequency of LN metastasis; however, we confirmed the independent prognostic value of histologic grading. A multimodal treatment may lead to favourable long\u2010term outcome. Moreover, the superficial cervical LN is most often the SLN.<\/jats:p>","DOI":"10.1111\/vco.12893","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T02:24:21Z","timestamp":1678674261000},"page":"332-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Patterns of nodal metastases, biological behaviour and prognosis of canine mast cell tumours of the pinna: A multi\u2010institutional retrospective study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-4303","authenticated-orcid":false,"given":"Carmit","family":"Chalfon","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Ozzano dell'Emilia 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Ferraris","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Turin  Grugliasco Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Ramos","sequence":"additional","affiliation":[{"name":"North Downs Specialist Referrals  Bletchingley UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9357-944X","authenticated-orcid":false,"given":"Gerry","family":"Polton","sequence":"additional","affiliation":[{"name":"North Downs Specialist Referrals  Bletchingley UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Schiavo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Cambridge Veterinary School University of Cambridge  Cambridge 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