{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:37:07Z","timestamp":1791819427265,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study we undertook a comprehensive analysis of a Pet Tumour Registry of the Canary Archipelago (PTR\u2010CA) in Spain to investigate the epidemiology of canine cutaneous round cell tumours. From a database of 2526 tumours collected from 2003 to 2020, we conducted a longitudinal analysis of the main trends in diagnosis, age, multiplicity and anatomical distribution as well as a case\u2013control study comparing these cases with the contemporaneous canine population of the Canary Archipelago to analyse breed distribution. In line with former studies, we found histiocytomas mostly affect young dogs (2, IQR 1\u20135) and mast cell tumours affect middle\u2010to\u2010old dogs (8, IQR 6\u201310) with grade 1 affecting at younger ages (6.5, IQR 6\u20138) than both grade 2 (8, IQR 6\u201310\u2009years) and grade 3 (9, IQR 7\u201311). Histiocytomas and plasmacytomas showed a similar anatomical distribution appearing mainly on the face, head and neck regions while mast cell tumours occur mainly on limbs and trunk. Higher risk for mast cell tumours and histiocytomas were found for Bulldog\u2010related breeds such as Boxer (OR<jats:sub>MCT<\/jats:sub>\u2009=\u200923.61, CI95%: 19.12\u201329.15, OR<jats:sub>HCT<\/jats:sub>\u2009=\u200910.17, CI95%: 6.60\u201315.67), Boston Terrier (OR<jats:sub>MCT<\/jats:sub> 19.47, CI95%: 7.73\u201349.05, OR<jats:sub>HCT<\/jats:sub> 32.61, CI95%: 11.81\u201390.07) and Pug (OR<jats:sub>MCT<\/jats:sub> 8.10, CI95%: 5.92\u201311.07, OR<jats:sub>HCT<\/jats:sub> 7.87, CI95%: 4.66\u201313.28) while Chihuahua dogs showed significantly less risk (OR<jats:sub>MCT<\/jats:sub> 0.18, CI95%: 0.09\u20130.33, OR<jats:sub>HCT<\/jats:sub> 0.41, CI95%: 0.21\u20130.78). Notably, the Canarian Mastiff, a local breed, had a low risk of suffering from a mast cell tumour which raises the question of whether this relates to a genetic peculiarity of this breed or some husbandry and environmental factor.<\/jats:p>","DOI":"10.1111\/vco.12899","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T05:45:23Z","timestamp":1683265523000},"page":"406-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Epidemiology of canine cutaneous round cell tumours on the canary archipelago in Spain"],"prefix":"10.1111","volume":"21","author":[{"given":"Jos\u00e9","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Institute for Animal Health and Food Safety University of Las Palmas de Gran Canaria  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngelo","family":"Santana","sequence":"additional","affiliation":[{"name":"Mathematics Department University of Las Palmas de Gran Canaria  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa Andrada","family":"Borzollino","sequence":"additional","affiliation":[{"name":"Institute for Animal Health and Food Safety University of Las Palmas de Gran Canaria  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Herr\u00e1ez","sequence":"additional","affiliation":[{"name":"Institute for Animal Health and Food Safety University of Las Palmas de Gran Canaria  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8787-7651","authenticated-orcid":false,"given":"David R.","family":"Killick","sequence":"additional","affiliation":[{"name":"Institute of Infection, Veterinary Science and Ecology University of Liverpool  Neston UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Espinosa","family":"de los Monteros","sequence":"additional","affiliation":[{"name":"Institute for Animal Health and Food Safety University of Las Palmas de Gran Canaria  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2002.tb00066.x"},{"key":"e_1_2_10_3_1","first-page":"5","article-title":"Canine neoplasia\u2013introductory paper","volume":"125","author":"Gamlem H","year":"2008","journal-title":"J Pathol Microbiol Immunol [Internet]"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2008.0133.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-5-39"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.b4808"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"31","article-title":"Incidence and types of canine tumours in Croatia","volume":"83","author":"\u0160o\u0161tari\u0107\u2010Zuckermann IC","year":"2013","journal-title":"Vet Arch [Internet]"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1126-0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2015.02.005"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-021-01039-x"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"295","article-title":"Survey of animal neoplasms in alameda and contra costa counties, California","volume":"40","author":"Dorn CR","year":"1968","journal-title":"I Methodology and Description of Cases J Natl Cancer Inst [Internet]"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"146","article-title":"Diagnostic immunohistochemistry for canine cutaneous round cell tumours \u2014 retrospective analysis of 60 cases","volume":"57","author":"Pazdzior\u2010Czapula K","year":"2019","journal-title":"Folia Histochem Cytobiol"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.239.7.960"},{"issue":"2","key":"e_1_2_10_14_1","first-page":"307","article-title":"Survey of animal neoplasms in alameda and contra costa counties, California. 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