{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:21:40Z","timestamp":1769264500334,"version":"3.49.0"},"reference-count":72,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T00:00:00Z","timestamp":1684022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neoadjuvant chemotherapy can be used in canine mast cell tumours (MCTs) to optimise surgical margins or to enable marginal excision in challenging locations. The objective of this study was to describe the outcome of dogs with cutaneous and subcutaneous MCTs treated with neoadjuvant vinblastine\u2010prednisolone (NA\u2010VP). Records of treatment\u2010na\u00efve dogs with cutaneous\/subcutaneous MCT that received NA\u2010VP were reviewed including signalment, indication for NA\u2010VP, staging results, clinical response, surgical data and histopathology reports. For dogs with post\u2010operative follow\u2010up \u2265365\u2009days, predictive factors for local recurrence (LR) were evaluated. Forty\u2010four dogs were included. NA\u2010VP was indicated to optimise surgical margins (group MARG) in 19 dogs (43.2%) and to enable surgery (group MORB) in 25 dogs (56.8%). Complete and partial response were documented in 40.9% of dogs and 30 dogs (68.2%) underwent surgery. The indication for NA\u2010VP was significantly associated with undergoing surgery (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) on multivariable analysis. Twelve (48%) and 18 dogs (94.7%) underwent surgery in the group MORB and MARG, respectively. Five dogs (16.7%) experienced wound dehiscence. Complete excision was achieved in 14 dogs (46.7%). In dogs undergoing surgery with \u2265365\u2009days of follow\u2010up, LR was documented in five cases (20.8%). None of the factors analysed including mitotic count, completeness of excision and response to NA\u2010VP were associated with LR; notably, LR occurred in 3\/11 (27.2%) completely excised MCTs. In a pre\u2010operative setting, NA\u2010VP appears safe and could be beneficial in selected cases. Prognostic factors such as clinical response, mitotic count and completeness of excision should be interpreted with caution following NA\u2010VP.<\/jats:p>","DOI":"10.1111\/vco.12904","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T03:31:01Z","timestamp":1684121461000},"page":"447-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pre\u2010operative neoadjuvant vinblastine\u2010prednisolone in canine mast cell tumours: A single\u2010centre retrospective cohort study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2726-7691","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Ossowska","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Alvarez","family":"Picornell","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Finotello","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Veterinary Science University of Liverpool  Neston UK"},{"name":"Department of Veterinary Medicine University of Bari  Valenzano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Amores\u2010Fuster","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Veterinary Science University of Liverpool  Neston UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-9503","authenticated-orcid":false,"given":"Jean\u2010Benoit","family":"Tanis","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Veterinary Science University of Liverpool  Neston UK"},{"name":"Department of Molecular &amp; Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology University of Liverpool  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00341.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040618"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-019-2227-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.243.10.1436"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/cco.2018.09.05"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004893"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-11236-y"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082251"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10807"},{"issue":"3","key":"e_1_2_11_11_1","first-page":"421","article-title":"Neoadjuvant chemoradiotherapy or chemotherapy? 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