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The purpose of this prospective study was to describe a reliable, quick, and inexpensive technique for SLN mapping in canine patients affected by cutaneous and subcutaneous mast cell tumours (MCT). Eighty dogs were enrolled in this study for a total of 138 cytologically diagnosed MCTs. Sentinel lymph node mapping was performed by injecting iomeprole peritumorally followed by serial radiographs at 1, 3, 6 and 9\u2010min post injection. A total of 168 SLNs were detected, 90% at first radiograph, 1\u2009min after the peritumoral iomeprole injection, while in the rest of the cases SLN was identified at 3\u2009min. Sentinel lymph nodes detected by the preoperative radiographic indirect lymphography with iomeprole (PRILI) differed from regional lymph nodes in 57% of cases. The PRILI technique detected simultaneously multiple SLNs in the 26% of cases and multiple lymph centers in the 31% of MCTs. To allow the surgical identification of the SLNs, a peritumoral injection of methylene blue was performed at the time of surgery. This study reports a widely available technique for SLN mapping using digital radiographs in combination with a water\u2010soluble medium, representing a cost\u2010effective alternative to other SLN mapping procedures. Based on our results, this technique can be effective for SLNs mapping in dogs with MCTs but further comparative studies are needed to assess its reliability and efficacy in different tumours.<\/jats:p>","DOI":"10.1111\/vco.12906","type":"journal-article","created":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T09:14:33Z","timestamp":1684228473000},"page":"469-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Sentinel lymph node mapping in canine mast cell tumours using a preoperative radiographic indirect lymphography: Technique description and results in 138 cases"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4426-5871","authenticated-orcid":false,"given":"Maurizio","family":"Annoni","sequence":"first","affiliation":[{"name":"Department of Soft Tissue and Oncologic Surgery AniCura Clinica Veterinaria Tibaldi  Milan 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