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Earlier publications reporting on the use of non\u2010modulated radiation therapy suggested a poor prognosis for dogs with glioma, with median survival times ranging between 4 and 6\u2009months; more recent literature utilizing stereotactic radiation therapy (SRT) demonstrates that the prognosis for canine gliomas may be more promising, with survival times closer to 12\u2009months. A single institution retrospective study was performed between 2010 and 2020 investigating the outcomes of dogs with biopsy\u2010confirmed glioma or a presumptive diagnosis of intra\u2010cranial glioma based on MRI characteristics that were treated with SRT. Twenty\u2010three client\u2010owned dogs were included. Brachycephalic breeds were overrepresented, totalling 13 dogs (57%). SRT protocols included 16\u2009Gy single fraction (<jats:italic>n<\/jats:italic>\u2009=\u20091, 4%), 18\u2009Gy single fraction (<jats:italic>n<\/jats:italic>\u2009=\u20091, 4%), 24\u2009Gy in 3 daily fractions (<jats:italic>n<\/jats:italic>\u2009=\u200920, 91%), or 27\u2009Gy in four daily fractions (<jats:italic>n<\/jats:italic>\u2009=\u20091, 4%). Twenty\u2010one dogs (91%) had improvement of their presenting clinical signs following SRT. Median overall survival time (MST) was 349\u2009days (95% CI, 162\u2013584). Median disease specific survival time was 413\u2009days (95% CI, 217\u2013717). When SRT is incorporated into the management plan for dogs with confirmed or presumed intracranial glioma, a median survival time of approximately 12\u2009months may be achievable.<\/jats:p>","DOI":"10.1111\/vco.12920","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T00:03:08Z","timestamp":1688947388000},"page":"578-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Efficacy of stereotactic radiation therapy for the treatment of confirmed or presumed canine glioma"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9974-0046","authenticated-orcid":false,"given":"Erin","family":"Trageser","sequence":"first","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4861","authenticated-orcid":false,"given":"Tiffany","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Braden","family":"Burdekin","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cullen","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Del","family":"Leary","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"LaRue","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-4502","authenticated-orcid":false,"given":"Mary\u2010Keara","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2006.tb02913.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810363486"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12432"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6511-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01151"},{"key":"e_1_2_7_7_1","article-title":"Survival time after surgical Debulking and Temozolomide adjuvant chemotherapy in canine intracranial gliomas","volume":"9","author":"Hidalgo Crespo E","year":"2022","journal-title":"Vet Sci"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12573"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12401"},{"issue":"4","key":"e_1_2_7_10_1","first-page":"241","article-title":"Preliminary study of lomustine in the treatment of intracranial masses in dogs following localization by imaging techniques","volume":"5","author":"Fulton LM","year":"1990","journal-title":"Semin Vet Med Surg"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1999.tb01454.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6823(1997)5:1<8::AID-ROI2>3.0.CO;2-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1991.tb00952.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-020-02614-x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12316"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12703"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16472"},{"key":"e_1_2_7_18_1","unstructured":"Society VC.Clinical Trials. 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