{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:25Z","timestamp":1787016145139,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Adrenalectomies for canine adrenal tumours are associated with peri\u2010operative morbidity and mortality. Objectives of this study included assessing the prognostic value of tumour\u2010 or surgery\u2010related variables in predicting peri\u2010operative mortality and overall survival in dogs undergoing adrenalectomies for primary adrenal tumours as well as pre\u2010treatment with phenoxybenzamine on survival to discharge with pheochromocytomas specifically. A multi\u2010institutional retrospective cohort study was performed across nine institutions. Electronic medical record searches identified 302 dogs which met the inclusion criteria. Data collected included dog\u2010related, tumour\u2010related, treatment\u2010related, surgery\u2010related, and outcome variables. Univariate and multivariable logistic regression and cox proportional hazards models were used to identify variables associated with death prior to discharge and tumour\u2010related survival. Overall, 87% of dogs survived to discharge with a tumour\u2010related survival time of 3.96\u2009years. Post\u2010operative complications were reported in 25%. Increased surgical time (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002) and pre\u2010surgical medical treatment other than phenoxybenzamine (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024) were significantly associated with increased peri\u2010operative mortality while ureteronephrectomy (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), post\u2010operative pancreatitis (p\u2009=\u20090.025), and post\u2010operative aspiration pneumonia (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) were significantly associated with decreased overall survival. Phenoxybenzamine pretreatment had no effect on peri\u2010operative mortality. Thirty\u2010seven of 45 (82%) dogs with pheochromocytomas not pretreated survived to discharge, and 50 of 59 (85%) dogs with pheochromocytomas pretreated with phenoxybenzamine survived to discharge (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.730). This study provides information on risk factors for death prior to discharge and tumour\u2010related survival that may help guide clinical management and owner expectations. In addition, the study findings challenge the previously reported benefit of phenoxybenzamine for pretreatment of dogs undergoing adrenalectomies for pheochromocytomas.\n                  <\/jats:p>","DOI":"10.1111\/vco.12931","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T21:39:26Z","timestamp":1693517966000},"page":"673-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Risk factors influencing death prior to discharge in 302 dogs undergoing unilateral adrenalectomy for treatment of primary adrenal gland tumours"],"prefix":"10.1111","volume":"21","author":[{"given":"Hunter J.","family":"Piegols","sequence":"first","affiliation":[{"name":"The Ohio State University Veterinary Medical Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany E.","family":"Abrams","sequence":"additional","affiliation":[{"name":"The Ohio State University Veterinary Medical Center The Ohio State University  Columbus Ohio USA"},{"name":"Ryan Veterinary Hospital Unviersity of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis M.","family":"Lapsley","sequence":"additional","affiliation":[{"name":"The Ohio State University Veterinary Medical Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan T.","family":"Cray","sequence":"additional","affiliation":[{"name":"The Ohio State University Veterinary Medical Center The Ohio State University  Columbus Ohio USA"},{"name":"Angell Animal Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine A.","family":"Dornbusch","sequence":"additional","affiliation":[{"name":"The Ohio State University Veterinary Medical Center The Ohio State University  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Murphy","sequence":"additional","affiliation":[{"name":"Angell Animal Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8458-1735","authenticated-orcid":false,"given":"Brandan G.","family":"Wustefeld\u2010Janssens","sequence":"additional","affiliation":[{"name":"Texas A&amp;M University Small Animal Teaching Hospital Texas A&amp;M University  College Station Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos H.","family":"Souza","sequence":"additional","affiliation":[{"name":"UF Small Animal Hospital University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Traverson","sequence":"additional","affiliation":[{"name":"NC State Veterinary Hospital North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Amsellem","sequence":"additional","affiliation":[{"name":"The University of Minnesota Veterinary Medical Center University of Minnesota  St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elroy","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Missouri Veterinary Health Center University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen T.","family":"Skinner","sequence":"additional","affiliation":[{"name":"University of Missouri Veterinary Health Center University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3767-7157","authenticated-orcid":false,"given":"Julius M.","family":"Liptak","sequence":"additional","affiliation":[{"name":"VCA Canada Alta Vista Animal 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5669"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12105.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13221"},{"issue":"1","key":"e_1_2_7_5_1","first-page":"O99","article-title":"A comparison of outcomes between laparoscopic and open adrenalectomies in dogs","volume":"50","author":"Taylor CJ","year":"2021","journal-title":"Vet 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