{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:20:48Z","timestamp":1787016048275,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Haemangiosarcoma is a relatively common malignant tumour in dogs, and one of the primary outcomes of interest for the Golden Retriever Lifetime Study. This study collects longitudinal data and samples from a cohort of golden retrievers, with the aim of identification of nutritional, genetic, environmental, lifestyle and reproductive risk factors for cancers and other important diseases in dogs. This analysis describes the accumulating data and samples, which are available for use by researchers to fulfil the study's objectives. As of September 2022, 233\/3044 dogs enrolled in the study had been diagnosed with haemangiosarcoma (7.65%), with an incidence rate of 1.10 cases per 100 dog\u2010years. Visceral haemangiosarcoma was the most common, affecting 211\/3044 study dogs (6.9%). One hundred and twenty eight visceral haemangiosarcoma diagnoses specified the presence of splenic tumours (60.7%) and 119 specified the presence of cardiac tumours (56.4%). The probability of remaining without a haemangiosarcoma diagnosis declined from 100% from approximately 4\u2009years of age, to a 12 year probability of 91.1% in intact females (95% CI 84.4%\u201398.3%), 60.7% in neutered females (95% CI 41.6%\u201388.6%), 72.9% in intact males (95% CI 62.9%\u201384.6%) and 70.0% in neutered males (95% CI 53.4%\u201392.0%). The 1 year survival probability for visceral haemangiosarcoma was 1.42% (95% CI 0.37%\u20135.47%); for cutaneous haemangiosarcoma, it was 84.6% (95% CI 67.1%\u201399.99%). The accumulated data and samples are a considerable resource for further investigation of canine haemangiosarcoma and have a potential role in translational medicine.<\/jats:p>","DOI":"10.1111\/vco.12933","type":"journal-article","created":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T23:04:10Z","timestamp":1693177450000},"page":"700-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Descriptive analysis of haemangiosarcoma occurrence in dogs enrolled in the\n                    <scp>G<\/scp>\n                    olden\n                    <scp>R<\/scp>\n                    etriever lifetime study"],"prefix":"10.1111","volume":"21","author":[{"given":"Alison","family":"Hillman","sequence":"first","affiliation":[{"name":"Ausvet  Fremantle Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenna","family":"Swafford","sequence":"additional","affiliation":[{"name":"Scientific Programs Department Morris Animal Foundation  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Delavenne","sequence":"additional","affiliation":[{"name":"Ausvet Europe  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hille","family":"Fieten","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Boerkamp","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Tietje","sequence":"additional","affiliation":[{"name":"Scientific Programs Department Morris Animal Foundation  Denver Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0230"},{"key":"e_1_2_9_3_1","unstructured":"Morris Animal Foundation.Advancing Canine Health.2022Accessed November 29 2022.https:\/\/www.morrisanimalfoundation.org\/golden-retriever-lifetime-study-rfp"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/104063870401600606"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195\u20105616(03)00002\u20100"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prevetmed.2020.105074"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589202900406"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/vetsci2040388"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463\u20105224.2006.00471.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005549"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilu010"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11071872"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40575\u2010017\u20100053\u20105"},{"issue":"1","key":"e_1_2_9_14_1","first-page":"23","article-title":"Human and animal sentinels for shared health risks","volume":"45","author":"Rabinowitz P","year":"2009","journal-title":"Vet Ital"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/cts.2020.548"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2020.04.026"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0269425"},{"key":"e_1_2_9_18_1","unstructured":"R Core Team.R: A language and environment for statistical computing.2020https:\/\/www.R-project.org\/"},{"key":"e_1_2_9_19_1","unstructured":"TherneauT.A package for survival analysis in R.2023https:\/\/cran.r-project.org\/web\/packages\/survival\/vignettes\/survival.pdf"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0280795"},{"key":"e_1_2_9_21_1","unstructured":"Morris Animal Foundation.Morris Animal Foundation Data Commons.2022. Accessed May 24 2022https:\/\/datacommons.morrisanimalfoundation.org\/"},{"key":"e_1_2_9_22_1","unstructured":"Morris Animal Foundation.MAF Data Commons Terms and Conditions of Use. Morris Animal Foundation Data Commons.2019. Accessed June 8 2022https:\/\/datacommons.morrisanimalfoundation.org\/terms-conditions"},{"key":"e_1_2_9_23_1","unstructured":"Morris Animal Foundation.Golden Retriever Lifetime Study \u2013 data and samples available for research.2022. Accessed January 4 2023https:\/\/www.morrisanimalfoundation.org\/golden-retriever-lifetime-study-rfp"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780198735564.003.0011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049044"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229728"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431\u2010019\u20100513\u20103"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sdata.2016.18"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T04:12:54Z","timestamp":1702095174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,27]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1111\/vco.12933"],"URL":"https:\/\/doi.org\/10.1111\/vco.12933","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,27]]},"assertion":[{"value":"2023-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}