{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:22:39Z","timestamp":1787016159975,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T00:00:00Z","timestamp":1698883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Due to the low frequency and the changes in diagnostic techniques and terminology during the last few years, only little clinical information is available on splenic stromal sarcoma (SSS). This multi\u2010institutional study aimed at gathering clinical cases of SSS in dogs and investigates their clinical behaviour, as well as analyse possible clinicopathological prognostic factors, including the use of adjuvant therapy. Dogs with a histologically confirmed SSS that underwent splenectomy were retrospectively included. To be included in the study, either FFPE tissue blocks or multiple tissue sections had to be available for histopathologic and immunohistochemical revision. Clinical and pathological variables, along with adjuvant therapy data, were collected. Cumulative incidence of metastatic disease was analysed through univariate and bivariate analyses. The impact of adjuvant chemotherapy on metastasis incidence and survival was assessed, considering an estimated propensity score. A total of 32 dogs were included. Among them, 22 developed metastases with an incidence of 37.5%, 59.38%, and 65.94% at 6, 12, and 24\u2009months, respectively. Univariate analysis identified mitotic count, total scoring, and necrosis as prognostic factors. In bivariate analysis, mitotic count remained prognostic. The administration of adjuvant chemotherapy did not have an impact on metastasis incidence or survival time. The study found that dogs with SSSs are at high risk of metastasis, although a small subgroup may experience longer survival after splenectomy. Mitotic count was the only variable having a reliable prognostic impact. Adjuvant chemotherapy did not appear to decrease the incidence of metastasis or prolong survival in these dogs.<\/jats:p>","DOI":"10.1111\/vco.12941","type":"journal-article","created":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T20:49:41Z","timestamp":1698958181000},"page":"12-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Splenic stromal sarcomas in dogs: Outcome and clinicopathological prognostic factors in 32 cases"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7960-6165","authenticated-orcid":false,"given":"Roberta","family":"Ferrari","sequence":"first","affiliation":[{"name":"Dipartimento di Medicina Veterinaria e Scienze Animali Universit\u00e0 degli Studi di Milano  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"Laura","family":"Marconato","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Veterinarie, Alma Mater Studiorum Universit\u00e0 di Bologna  Ozzano dell'Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Boracchi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Cliniche e di Comunit\u00e0, Laboratorio di Statistica Medica, Biometria ed Epidemiologia \u201cG.A. Maccacaro\u201d Universit\u00e0 degli Studi di Milano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-0366","authenticated-orcid":false,"given":"Damiano","family":"Stefanello","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Veterinaria e Scienze Animali Universit\u00e0 degli Studi di Milano  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Godizzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Veterinaria e Scienze Animali Universit\u00e0 degli Studi di Milano  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Murgia","sequence":"additional","affiliation":[{"name":"Dick White Referrals  Six Mile Bottom UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Schievenin","sequence":"additional","affiliation":[{"name":"Ospedale Veterinario \u201cCitt\u00e0 di Conegliano\u201d  Conegliano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Amati","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Veterinaria e Scienze Animali Universit\u00e0 degli Studi di Milano  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9566-9326","authenticated-orcid":false,"given":"Eugenio","family":"Faroni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Mediche Veterinarie, Alma Mater Studiorum Universit\u00e0 di Bologna  Ozzano dell'Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Roccabianca","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Veterinaria e Scienze Animali Universit\u00e0 degli Studi di Milano  Lodi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2460\/javma.1992.200.06.829","article-title":"Prevalence, type, and importance of splenic diseases in dogs: 1480 cases (1985\u20101989)","volume":"200","author":"Spangler WL","year":"1992","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_9_3_1","first-page":"250","article-title":"Splenic masses in dogs. 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