{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:42:49Z","timestamp":1789684969912,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T00:00:00Z","timestamp":1701561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early diagnosis of nodal metastasis has been shown to impact prognosis for dogs with mast cell tumours (MCT). The objective of this retrospective study was to determine the correlation between computed tomographic characteristics of lymph nodes and histologic nodal metastasis using the HN classification system, in dogs with cutaneous or subcutaneous MCT and regional lymph node(s) removal. Dogs that had removal of MCT and regional lymphadenectomy within 31\u2009days of the initial staging computed tomography (CT) were enrolled. Subjective lymph node characteristics used included margination, loss of fat at hilus, shape of margin, perinodal fat pattern, increase in number of nodes, and pre\u2010 and post\u2010contrast heterogeneity. Enhancement, heterogeneity, and short\u2010long axis ratio were calculated. Seventy\u2010one lymph nodes from 37 dogs were included. Generalised linear mixed model of assessment of lymph node was performed twice, with binary outcome [non\u2010metastatic (HN0\/1) versus metastatic (HN2\/3)] and 4\u2010point scales (HN0\u2013HN3). After blind assessment of 7 characteristics described above, a final subjective interpretation of each lymph node as non\u2010metastatic or metastatic was assigned. A significant correlation was found between final interpretation and prediction of metastasis. Higher HN classification was also significantly correlated with the increased number of nodes and pre\u2010 and post\u2010contrast heterogeneity. No correlation was found in short\u2010long axis ratio, calculated heterogeneity, or degree of enhancement. Sensitivity of CT was 35.7%, specificity was 96.6%, and accuracy was 60.5% for nodal metastasis. CT alone cannot be recommended for assessment of metastasis. The use of multiple computed tomographic characteristics may increase accuracy of nodal metastasis detection.<\/jats:p>","DOI":"10.1111\/vco.12947","type":"journal-article","created":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T23:14:45Z","timestamp":1701645285000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Correlation between computed tomography and histological evaluation of nodal metastasis in dogs with mast cell tumours"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2740-5245","authenticated-orcid":false,"given":"Hiroshi","family":"Miyagi","sequence":"first","affiliation":[{"name":"The Department of Clinical Sciences Oregon State University Carlson College of Veterinary Medicine  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6405-0793","authenticated-orcid":false,"given":"Katy L.","family":"Townsend","sequence":"additional","affiliation":[{"name":"The Department of Clinical Sciences Oregon State University Carlson College of Veterinary Medicine  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa Michael","family":"Ettinger","sequence":"additional","affiliation":[{"name":"The Department of Clinical Sciences Oregon State University Carlson College of Veterinary Medicine  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-6133","authenticated-orcid":false,"given":"Duncan S.","family":"Russell","sequence":"additional","affiliation":[{"name":"The Department of Biomedical Sciences Oregon State University Carlson College of Veterinary Medicine  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Colee","sequence":"additional","affiliation":[{"name":"Institute of Farm and Agricultural Sciences, Statistics Consulting Unit University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren Elizabeth","family":"Newsom","sequence":"additional","affiliation":[{"name":"The Department of Clinical Sciences Oregon State University Carlson College of Veterinary Medicine  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-2362-5.00018-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-2362-5.00020-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5997"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12071"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2003.tb02501.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA-MS-5557"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810387446"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2014.07.004"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.2008.00694.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12012"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12256"},{"key":"e_1_2_10_13_1","first-page":"18","volume-title":"BSAVA Manual of Canine and Feline Oncology","author":"Dobson JM","year":"2003"},{"key":"e_1_2_10_14_1","first-page":"75","article-title":"Lymph node evaluation with diagnostic imaging, advances in small animal care","volume":"1","author":"Randall E","year":"2020","journal-title":"Elsevier"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12592"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12415"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069222"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12279"},{"key":"e_1_2_10_20_1","first-page":"542","volume-title":"Chapter 13: the Lymphatic System. 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