{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:01:53Z","timestamp":1792504913845,"version":"4.5.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Large granular lymphocyte lymphoma (LGLL) is a rare form of lymphoma in dogs. Limited information exists regarding presentation, treatment response, and outcome. The aim of this single\u2010institute, retrospective study was to characterise clinical presentation, biologic behaviour, outcomes, and prognostic factors for dogs with LGLL. Cytologic review was also performed. Sixty\u2010five dogs were included. The most common breed was the Labrador retriever (29.2%), and the most common presenting signs were lethargy (60.0%) and hyporexia (55.4%). The most common primary anatomic forms were hepatosplenic (32.8%) and gastrointestinal (20.7%). Twenty dogs (30.8%) had peripheral blood or bone marrow involvement. Thirty\u2010two dogs were treated with maximum tolerated dose chemotherapy (MTDC) with a response documented in 74.1% of dogs. Dogs \u22657\u2009years, and those with neutropenia or thrombocytopenia at diagnosis had the reduced likelihood of response to treatment. For dogs treated with MTDC median progression\u2010free interval (PFI) was 17\u2009days (range, 0\u2013481), the median overall survival time (OST) 28\u2009days (range, 3\u2013421), and the 6\u2010month and 1\u2010year survival rates were 9.4% and 3.1%, respectively. On multivariable analysis, monocytosis and peripheral blood involvement were significantly associated with shorter PFI and OST. Long\u2010term survival (\u2265100\u2009days) was significantly associated with intermediate lymphocyte size on cytology. Dogs with LGLL have moderate response rates to chemotherapy but poor overall survival. Additional studies are needed to further evaluate prognostic factors and guide optimum treatment recommendations.<\/jats:p>","DOI":"10.1111\/vco.12959","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T04:32:00Z","timestamp":1703824320000},"page":"115-124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Large granular lymphocyte lymphoma in 65 dogs (2005\u20132023)"],"prefix":"10.1111","volume":"22","author":[{"given":"Andrew D.","family":"Yale","sequence":"first","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia L.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Department of Clinical Science and Services Royal Veterinary College  Hatfield 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