{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:10:47Z","timestamp":1784826647035,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T00:00:00Z","timestamp":1705795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canine craniomaxillofacial osteosarcoma (OSA) is most commonly treated surgically; however, in cases where surgery is not feasible or non\u2010invasive treatment is desired, stereotactic body radiation therapy (SBRT) may be elected for local tumour control. In this study, we evaluated 35 dogs treated with SBRT. Nine dogs (26%) had calvarial, seven (20%) had mandibular and 19 (54%) had maxillary OSA. Median time to first event (TFE) was 171\u2009days, and overall median survival time (MST) was 232\u2009days. Site\u2010specific MSTs were 144\u2009days for mandible, 236\u2009days for calvarium and 232\u2009days for maxilla (<jats:italic>p<\/jats:italic>\u2009=\u2009.49). Pulmonary metastatic disease was observed in 12\/35 (34%) patients and was detected pre\u2010SBRT in six dogs (17%) and post\u2010SBRT in the remaining six dogs (17%). Eighteen adverse events post\u2010SBRT were documented. Per veterinary radiation therapy oncology group criteria, five were acute (14%) and three were late (9%) grade 3 events. Neurological signs in two dogs were suspected to be early\u2010delayed effects. Cause of death was local progression for 22\/35 (63%) patients, metastasis for 9\/35 (26%) patients and unknown for four. On univariate analysis, administration of chemotherapy was associated with a longer TFE (<jats:italic>p<\/jats:italic>\u2009=\u2009.0163), whereas volume of gross tumour volume was associated with a shorter TFE (<jats:italic>p<\/jats:italic>\u2009=\u2009.023). Administration of chemotherapy and five fractions versus single fraction of SBRT was associated with increased survival time (<jats:italic>p<\/jats:italic>\u2009=\u2009.0021 and .049). Based on these findings, a treatment protocol incorporating chemotherapy and five fractions of SBRT could be considered for dogs with craniomaxillofacial OSA electing SBRT with careful consideration of normal tissues in the field.<\/jats:p>","DOI":"10.1111\/vco.12960","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T01:49:18Z","timestamp":1705888158000},"page":"125-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes of 35 dogs with craniomaxillofacial osteosarcoma treated with stereotactic body radiation therapy"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5872-099X","authenticated-orcid":false,"given":"Johnny","family":"Altwal","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3648-5946","authenticated-orcid":false,"given":"Ber\u2010In","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7239-4502","authenticated-orcid":false,"given":"Mary\u2010Keara","family":"Boss","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4602-4572","authenticated-orcid":false,"given":"Susan M.","family":"LaRue","sequence":"additional","affiliation":[{"name":"Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4861","authenticated-orcid":false,"given":"Tiffany Wormhoudt","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-43085-6_14"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.1992.tb00069.x"},{"key":"e_1_2_9_4_1","first-page":"263","volume-title":"Tumors in Domestic Animals","author":"Thompson 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