{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:47:59Z","timestamp":1785509279137,"version":"3.56.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:00:00Z","timestamp":1705708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Canine cutaneous mastocytosis (CM) is rare in contrast to canine mast cell tumours. In humans, CM commonly affects children and is usually indolent with possible spontaneous resolution. Systemic mastocytosis (SM) with bone marrow involvement typically affects adults, can have a poor outcome, and often includes skin lesions. \u2018Mastocytosis in the skin\u2019 (MIS) is the preferred term of skin lesions, if bone marrow evaluations are not available, which is often the cases in dogs. In human SM and CM, <jats:italic>KIT<\/jats:italic> mutations are often detected. The veterinary literature suggests clinical resemblances between human and canine MIS, but data is limited, and <jats:italic>KIT<\/jats:italic> mutations are rarely assessed. This retrospective study describes clinicopathological findings, treatment and outcome of 11 dogs with suspected MIS. Dogs with multiple mast cell tumours were excluded. Histopathology reports (<jats:italic>n<\/jats:italic>\u2009=\u20095) or slides (<jats:italic>n<\/jats:italic>\u2009=\u20096) were reviewed. <jats:italic>KIT<\/jats:italic> mutation analysis including exons 8, 9, 11, 14 and 17 were analysed in eight dogs. Median age at diagnosis was 4\u2009years (range, 1\u201312). Typical clinical signs included multifocal to generalised nodules and papules. Histologically, skin lesions were characterised by dermal infiltration of well\u2010differentiated mast cells. <jats:italic>KIT<\/jats:italic> mutations were detected in 3\/8 dogs (exon 9: <jats:italic>n<\/jats:italic>\u2009=\u20092; exon 11: <jats:italic>n<\/jats:italic>\u2009=\u20091). One dog had mastocytaemia suggesting possible SM. Glucocorticoids were mostly successful with lesion improvement in all treated dogs (<jats:italic>n<\/jats:italic>\u2009=\u20098). This cohort highlights resemblances between human and canine MIS. Further studies are required to confirm these findings and establish diagnostic criteria for CM and MIS associated with SM in dogs.<\/jats:p>","DOI":"10.1111\/vco.12962","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T12:59:12Z","timestamp":1705755552000},"page":"136-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mastocytosis in the skin in dogs: A multicentric case series"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0757-6788","authenticated-orcid":false,"given":"Eleanor K.","family":"Wyatt","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Affolter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Borio","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Guillen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Services, Royal Veterinary College University of London  Hatfield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Verganti","sequence":"additional","affiliation":[{"name":"Oncology Service Dick White Referrals  Six Mile Bottom UK"},{"name":"Centre for Small Animal Studies Animal Health Trust  Newmarket UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Murphy","sequence":"additional","affiliation":[{"name":"Centre for Small Animal Studies Animal Health Trust  Newmarket UK"},{"name":"College of Medicine &amp; Veterinary Medicine, Royal (Dick) School of Veterinary Studies University of Edinburgh  Roslin UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiano","family":"Ballarini","sequence":"additional","affiliation":[{"name":"Diagnostica Piccoli Animali  Zugliano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frane","family":"Banovic","sequence":"additional","affiliation":[{"name":"Department of Small Animal Medicine and Surgery, College of Veterinary Medicine University of Georgia  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1019-9503","authenticated-orcid":false,"given":"Jean\u2010Benoit","family":"Tanis","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool  Liverpool UK"},{"name":"Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.281"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14573"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.08.034"},{"issue":"11","key":"e_1_2_9_5_1","article-title":"Updated diagnostic criteria and classification of mast cell disorders: a consensus proposal","volume":"5","author":"Valent P","year":"2021","journal-title":"Hema"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.12.022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2021.069"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2022.03.007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.755258"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2012.00341.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098589202900415"},{"issue":"9","key":"e_1_2_9_12_1","first-page":"351","article-title":"Disseminated mastocytosis in a dog","volume":"25","author":"Pukay BP","year":"1984","journal-title":"Can Vet J"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3164.1992.tb00167.x"},{"issue":"3","key":"e_1_2_9_14_1","first-page":"245","article-title":"Urticaria pigmentosa\u2010like disease in a dog","volume":"56","author":"Pariser MS","year":"2015","journal-title":"Can Vet J"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2015-0038"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.12702"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.20.06.0358"},{"issue":"12","key":"e_1_2_9_18_1","first-page":"881","article-title":"Cutaneous mucinosis and mastocytosis in a Shar\u2010Pei","volume":"40","author":"L\u00f3pez A","year":"1999","journal-title":"Can Vet J"},{"key":"e_1_2_9_19_1","first-page":"508","article-title":"Urticaria pigmentosa\u2010like disease in two dogs","volume":"29","author":"Jeromin AM","year":"1993","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/03009858231174452"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1040638720972500"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.1987.tb01990.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12373"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/vcp.13186"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/vde.13074"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985810386469"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5829.2011.00301.x"},{"key":"e_1_2_9_28_1","volume-title":"TNM Classification of Tumours in Domestic Animals","author":"Owen LN","year":"1980"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.12069"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2018.04.001"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588402100503"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300985815593349"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1354\/vp.41-4-371"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsap.13181"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13567"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15542"},{"issue":"4","key":"e_1_2_9_37_1","first-page":"1","article-title":"Mastocytosis and related entities: a practical roadmap","volume":"78","author":"Beyens M","year":"2022","journal-title":"Acta Clin Belg"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.117"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1992.tb00428.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12136"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-6148-3-19"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-08-0067"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-020-00581-5"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.77605"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22125"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.12962","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T06:32:52Z","timestamp":1707719572000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.12962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,20]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/vco.12962"],"URL":"https:\/\/doi.org\/10.1111\/vco.12962","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,20]]},"assertion":[{"value":"2023-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}