{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:28:27Z","timestamp":1782520107160,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Meningiomas are the most common feline primary brain tumours, and calvarial hyperostosis (CH) is frequently documented in association with this neoplastic entity. The clinical significance of and mechanisms driving the formation of CH in cats with meningiomas are poorly understood, although tumour invasion into the skull and tumour production of cytokines and enzymes have been implicated as causes of CH in humans. This retrospective study investigated relationships between signalment, MRI or CT imaging features, histopathologic tumour characteristics, alkaline phosphatase (ALP) isoenzyme concentrations, tumour expression of matrix metalloproteinases (MMP)\u20102, MMP\u20109, and interleukin\u20106 (IL\u20106), and progression free survival times (PFS) following surgical treatment in 27 cats with meningiomas with (<jats:italic>n<\/jats:italic>\u2009=\u200915) or without (<jats:italic>n<\/jats:italic>\u2009=\u200912) evidence of CH. No significant differences in breed, age, sex, body weight, tumour grade, tumour volume, peritumoral edema burden, ALP isoenzyme concentrations, tumour Ki\u201067 labelling indices or MMP\u20102 or MMP\u20109 expression and activity, or PFS were noted between cats with or without CH. There was a trend towards higher serum (<jats:italic>p<\/jats:italic>\u2009=\u2009.06) and intratumoral (<jats:italic>p<\/jats:italic>\u2009=\u2009.07) concentrations of IL\u20106 in cats with CH, but these comparisons were not statistically significant. Histologic evidence of tumour invasion into bone was observed in 5\/12 (42%) with CH and in no (0\/6) cats without CH, although this was not statistically significant (<jats:italic>p<\/jats:italic>\u2009=\u2009.07). Tumour invasion into bone and tumour production of IL\u20106 may contribute to the formation of meningioma associated CH in cats, although larger studies are required to further substantiate these findings and determine their clinical relevance.<\/jats:p>","DOI":"10.1111\/vco.12964","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T07:29:01Z","timestamp":1707463741000},"page":"174-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Magnetic resonance and computed tomographic imaging characteristics and potential molecular mechanisms of feline meningioma associated calvarial hyperostosis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3606-675X","authenticated-orcid":false,"given":"Michael R.","family":"Edwards","sequence":"first","affiliation":[{"name":"Department of Small Animal Clinical Sciences Virginia\u2010Maryland College of Veterinary 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