{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:10:40Z","timestamp":1790820640686,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Specific data regarding outcome of cats with high\u2010grade and large granular lymphocyte alimentary lymphoma (HGAL and LGL, respectively) treated with multi\u2010agent chemotherapy are scarce. The aims of this multi\u2010centric, retrospective study were to describe the outcome of cats with HGAL and LGL treated with COP\u2010 or CHOP\u2010based chemotherapy and to identify potential prognostic factors. Cats with a cytological or histological diagnosis of HGAL or LGL lymphoma treated with COP\u2010 or CHOP\u2010based protocol as first\u2010line chemotherapy were included. Data regarding diagnosis, staging, treatment and follow\u2010up were collected. Fifty\u2010seven cats treated with CHOP (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200937) or COP (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200920) protocols were included. Complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD) were observed in 20%, 22%, 36% and 22% of cats, respectively, for an overall response rate of 42%. Median progression\u2010free interval (PFI) was 148\u2009days and overall median survival time (OST) was 131\u2009days. Cats achieving CR, PR or SD showed significantly longer PFI (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01) and OST (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.015) compared with cats with PD. Other positive prognostic factors in multi\u2010variate analysis were rescue treatment (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.001) and absence of lymph node involvement (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.03). Negative prognostic factors were diffuse infiltration of the gastrointestinal tract (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u2009.035) and infiltration of a non\u2010haematopoietic organ (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.01).\n                  <\/jats:p>","DOI":"10.1111\/vco.12965","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:55:54Z","timestamp":1707958554000},"page":"186-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Feline high\u2010grade and large granular lymphocyte alimentary lymphomas treated with\n                    <scp>COP<\/scp>\n                    \u2010 or\n                    <scp>CHOP<\/scp>\n                    \u2010based chemotherapy: A multi\u2010centric retrospective study of 57 cases"],"prefix":"10.1111","volume":"22","author":[{"given":"Gr\u00e9goire","family":"Bernardo Marques","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Ponce","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Beaudu\u2010Lange","sequence":"additional","affiliation":[{"name":"Clinique v\u00e9t\u00e9rinaire de la Pierre Bleue  Pipriac France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"B\u00e9guin","sequence":"additional","affiliation":[{"name":"Ecole Nationale V\u00e9t\u00e9rinaire d'Alfort\u2014CHUVA, Service de M\u00e9decine Interne  Maisons\u2010Alfort 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