{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:03:17Z","timestamp":1776913397853,"version":"3.51.2"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osteosarcoma is the most common malignant primary bone cancer, but it is infrequently reported in cats. Feline appendicular osteosarcoma typically exhibits good prognosis when treated with surgery alone. A retrospective multi\u2010institutional study was conducted to identify possible prognostic factors. Cats diagnosed with appendicular osteosarcoma were included if initial staging and follow\u2010up information were available. Data including signalment, tumour characteristics, treatment modalities, and survival outcomes were collected and analysed. Fifty\u2010six cats were included; the femur was the most frequently affected bone. Eight cats had distant metastasis at admission and an additional 9 developed metastatic disease during follow\u2010up, resulting in an overall metastatic rate of 30%. Forty\u2010nine (87.5%) cats underwent surgery, and 4 also received adjuvant chemotherapy. Among operated cats, median time to local progression (TTLP), time to distant progression and tumour\u2010specific survival (TSS) were not reached. One\u2010 and 2\u2010year survival rates were 66% and 55%, respectively. Seven (12.5%) cats received no treatment; 1\u2010 and 2\u2010year survival rates were 25% and 0%, respectively. Operated cats had significantly longer TTLP (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and TSS (<jats:italic>P<\/jats:italic>\u2009=\u2009.001) compared with non\u2010operated cats. Among operated cats, young age negatively impacted local tumour progression, while the presence of distant metastasis at diagnosis was associated with a higher risk of tumour\u2010related death. This study reaffirms the good prognosis for cats with appendicular osteosarcoma undergoing surgery, but sheds light on some additional factors to consider. Accurate initial staging is recommended, as the metastatic rate may exceed many previous estimations. Surgery substantially extends survival time, whereas the role of chemotherapy remains uncertain.<\/jats:p>","DOI":"10.1111\/vco.12966","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T06:59:44Z","timestamp":1707375584000},"page":"198-203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A retrospective Italian Society of Veterinary Oncology (<scp>SIONCOV<\/scp>) study of 56 cats with appendicular osteosarcoma"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7843-615X","authenticated-orcid":false,"given":"Laura","family":"Marconato","sequence":"first","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Bologna  Ozzano Emilia 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