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We retrospectively assessed dogs treated with definitive\u2010intent chemoradiotherapy (12\u2009\u00d7\u20093.8\u2009Gy, various first\u2010line chemotherapeutics). Local tumour control, radiation toxicities and survival were evaluated. We classified radiation toxicities according to the previously published radiation toxicity scheme \u201cVRTOG\u201d as well as the updated version, \u201cVRTOG_v2.0\u201d. Fourteen dogs with transitional cell carcinoma of bladder \u00b1\u2009urethra (<jats:italic>n<\/jats:italic>\u2009=\u20098), +prostate (<jats:italic>n<\/jats:italic>\u2009=\u20093) or solely urethra (<jats:italic>n<\/jats:italic>\u2009=\u20093), were included. Median follow\u2010up was 298\u2009days (range 185\u20131798\u2009days), median overall survival 305\u2009days (95%CI\u2009=\u2009209;402) and 28.6% deaths were tumour\u2010progression\u2010related. Acute radiation toxicity was mild and self\u2010limiting with both classification systems: In VRTOG, 5 dogs showed grade 1, and 1 dog grade 2 toxicity. In VRTOG_v2.0, 2 dogs showed grade 1, 3 dogs grade 2, and 3 dogs grade 3 toxicity. Late toxicity was noted in 14.2% of dogs (2\/14) with the VRTOG, both with grade 3 toxicity. With VRTOG_v2.0, a larger proportion of 42.9% of dogs (6\/14) showed late toxicities: Four dogs grade 3 (persistent incontinence), 2 dogs grade 5 (urethral obstructions without PD resulting in euthanasia). At time of death, 5 dogs underwent further workup and only 3 were confirmed to have PD. With the updated VRTOG_v2.0 classification system, more dogs with probable late toxicity are registered, but it is ultimately difficult to distinguish these from disease progression as restaging remains to be the most robust determinant.<\/jats:p>","DOI":"10.1111\/vco.12973","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T06:34:53Z","timestamp":1711607693000},"page":"255-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Radiation toxicity grading after chemoradiotherapy of canine urinary tract carcinomas: Comparing <scp>VRTOG<\/scp> to <scp>VRTOG_v2.0<\/scp>"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8747-9098","authenticated-orcid":false,"given":"Carlotta","family":"Ahrens","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Vetsuisse Faculty University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Beatrice","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Vetsuisse Faculty University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0793-9005","authenticated-orcid":false,"given":"Valeria","family":"Meier","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Vetsuisse Faculty University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-2722","authenticated-orcid":false,"given":"Carla","family":"Rohrer Bley","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Vetsuisse Faculty University of Zurich  Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.01.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16078"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2012.00946.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12339"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12578"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.05.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.261"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.5776"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.01.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.09.058"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.090"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2001.tb00973.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13291"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12677"},{"key":"e_1_2_9_16_1","first-page":"32","article-title":"TNM classification of tumours in domestic animals","volume":"1","author":"Owen LN","year":"1980","journal-title":"World Health Organization"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12569"},{"key":"e_1_2_9_18_1","volume-title":"Miller's Anatomy of the Dog","author":"Evans H","year":"2012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12441"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.03.022"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(00)00518-6"},{"key":"e_1_2_9_22_1","unstructured":"Rohrer BleyC MeierV RobotkaJ SchneiderU.Image\u2010guided radiation therapy in the palliative management of large abdomino\u2010pelvic tumors. 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