{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:36:49Z","timestamp":1785811009541,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Although canine pituitary masses (PM) are increasingly treated with stereotactic radiotherapy (SRT), historical literature supports superior outcomes with conventional full\u2010course fractionated radiation therapy (FRT). A multi\u2010institutional retrospective study was performed, including dogs with PM treated from 2016 to 2022 with SRT (total dose 30 or 35\u2009Gy in 5 daily fractions) or FRT (total dose 50\u201354\u2009Gy in 19\u201320 daily fractions). The influence of potential prognostic\/predictive factors was assessed, including pituitary: brain height, pituitary: brain volume, sex, age and endocrine status (functional [F] vs. nonfunctional [NF] PM). Forty\u2010four dogs with PM were included (26\u2009F, 14 NF, 4 unknown). All patients completed protocols as scheduled (SRT\u2009=\u200927, FRT\u2009=\u200917) and two dogs had suspected Grade 1 acute neurotoxicity. During the first 6\u2009months after RT, 5\/27 (19%) dogs treated with SRT (4 F, 1 NF) and 3\/17 (18%) dogs treated with FRT (all F) died or were euthanised because of progressive neurologic signs. The overall median survival time was 608\u2009days (95% CI, 375\u2013840\u2009days). Young age at the time of treatment was significant for survival (<jats:italic>p<\/jats:italic>\u2009=\u20090.0288); the overall median survival time was 753\u2009days for dogs &lt;9\u2009years of age (95% CI, 614\u2013892\u2009days) and 445\u2009days for dogs \u22659\u2009years of age (95% CI, 183\u2013707\u2009days). Survival time was not associated with treatment type or any other factor assessed herein. A prospective study using standardised protocols would further validate the results of the present study and potentially elucidate the predictors of early death.<\/jats:p>","DOI":"10.1111\/vco.12991","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T04:23:31Z","timestamp":1718771011000},"page":"429-436","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes of Stereotactic Radiation Therapy Versus Fractionated Radiation Therapy in 44 Dogs With Pituitary Masses: A Multi\u2010Institutional Retrospective Study (2016\u20132022)"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4889-4560","authenticated-orcid":false,"given":"Tracy\u00a0L.","family":"Gieger","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Magestro","sequence":"additional","affiliation":[{"name":"Department of Small Animal Clinical Sciences Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian","family":"Walz","sequence":"additional","affiliation":[{"name":"Angell Memorial Animal Medical Center  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8249-1525","authenticated-orcid":false,"given":"Hiroto","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-9700","authenticated-orcid":false,"given":"Michael\u00a0W.","family":"Nolan","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine North Carolina State University  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.2019.1622819"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.13917"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12708"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1998.213.02.225"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-1676.2007.tb03060.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2018.01.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12627"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16724"},{"key":"e_1_2_9_10_1","first-page":"481","article-title":"Effects of Radiotherapy on Pituitary Corticotroph Macrotumors in Dogs","volume":"48","author":"De Fornel P.","year":"2007","journal-title":"Canadian Veterinary Journal"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12270"},{"key":"e_1_2_9_12_1","first-page":"789","article-title":"ACVR and ECVDI Consensus Statement: Reporting Elements for Toxicity Criteria of the Veterinary Radiation Therapy Oncology Group v2.0. Vet Comp","volume":"64","author":"Poirier V. J.","year":"2023","journal-title":"Oncologia"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8261.2009.01522.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12281"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3438081"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canrad.2011.04.003"},{"key":"e_1_2_9_17_1","first-page":"176","article-title":"Response Evaluation Criteria for Solid Tumors in Dogs (v1.0): A Veterinary Cooperative Oncology Group Consensus Document","volume":"3","author":"Nguyen S. 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