{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:30:00Z","timestamp":1792197000980,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Electrochemotherapy (ECT) with intravenous (IV) and\/or intratumoral (IT) bleomycin has shown considerable efficacy in the treatment of non\u2010resectable feline cutaneous squamous cell carcinoma (cSCC), boasting response rates of up to 95%, but other chemotherapy protocols have not yet been investigated. The objective of this prospective multicentre study was to compare the overall response rate (ORR) and progression\u2010free interval (PFI) between cats with cSCC treated with ECT using IT and IV carboplatin (IV\u2009+\u2009IT), IV carboplatin (IV) or IV bleomycin (IV). A total of 44 cats with unresectable cSCC across three centres were enrolled and treated with ECT using carboplatin IV\u2009+\u2009IT (<jats:italic>n<\/jats:italic>\u2009=\u200910), carboplatin IV (<jats:italic>n<\/jats:italic>\u2009=\u200911) or bleomycin IV (<jats:italic>n<\/jats:italic>\u2009=\u200923). Treatment response according to RECIST criteria was recorded at 2 and 4\u2009weeks post\u2010treatment, and patients were followed until disease progression and\/or death. All three groups were comparable regarding age, sex, weight, and lesion size. Adverse events were generally mild, localised and similar between groups. ORRs were 90.0% (carboplatin IV\u2009+\u2009IT), 90.9% (carboplatin IV) and 95.6% (bleomycin IV) and were not significantly different (<jats:italic>p<\/jats:italic>\u2009=\u20090.79). Median PFI was not reached for carboplatin IV\u2009+\u2009IT or carboplatin IV and was 566\u2009days for bleomycin IV, with no significant difference between the three groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.81). This study suggests that ECT using IV or IV\u2009+\u2009IT carboplatin is a reasonable alternative therapeutic option for managing cSCC, and further studies are warranted to compare outcomes between treatment protocols.<\/jats:p>","DOI":"10.1111\/vco.12995","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T11:34:37Z","timestamp":1721043277000},"page":"437-446","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of Three Chemotherapy Protocols With Electrochemotherapy for the Treatment of Feline Cutaneous Squamous Cell Carcinoma"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5940-7129","authenticated-orcid":false,"given":"Nicolas","family":"Diop","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5084-8892","authenticated-orcid":false,"given":"David","family":"Sayag","sequence":"additional","affiliation":[{"name":"ONCOnseil\u2014Unit\u00e9 d'expertise en oncologie v\u00e9t\u00e9rinaire  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire\u00a0Bernardo","family":"Marques","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Chamel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Chavalle","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Bapiste","family":"Eon","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Floch","sequence":"additional","affiliation":[{"name":"AniCura TRIOVet  Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Lajoinie","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Ponce","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura\u00a0E.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon, VetAgro Sup, Service de canc\u00e9rologie, UR ICE  Marcy l'Etoile France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13483238"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X13507071"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2006.00145.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2005.00014.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.5326\/15473317-33-4-329"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-017-1018-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18822409"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2005.12.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.231.5.736"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1996.57.02.205"},{"issue":"12","key":"e_1_2_8_12_1","first-page":"1575","article-title":"Cisplatin Chemotherapy for Metastatic Squamous Cell Carcinoma in Two Dogs","volume":"189","author":"Himsel C. 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