{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:02:40Z","timestamp":1780624960404,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Neutropenia is a common chemotherapy\u2010associated adverse event (AE) in dogs and a significant cause of decreased relative dose intensity. Dose reductions (DRs) and treatment delays (TDs) are frequently applied to decrease the risk of further neutropenic events (NEs) and AEs, but there is no standardised approach. The two main objectives of this retrospective study were to determine: (1) the failure rate of a 10% DR to prevent a subsequent inadequate absolute neutrophil count (ANC), defined as a nadir ANC &lt;0.75\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L or pretreatment ANC &lt;1.5\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L; and (2) if the duration of TDs due to pretreatment neutropenia affects the occurrence of subsequent NEs. A total of 1056 chemotherapy treatments were recorded for 128 dogs that developed at least one NE. In 75 of 124 (60.5%, 95% CI: 51.2%\u201369%) evaluable NEs, a nadir ANC of \u22650.75\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L and pretreatment ANC of \u22651.5\u2009\u00d7\u200910\n                    <jats:sup>9<\/jats:sup>\n                    \/L were achieved after a single 10% chemotherapy DR, while a 10% DR failed to prevent a subsequent inadequate ANC in the remaining 49\/124 (39.5%, 95% CI: 30.1%\u201348.3%). The only variable associated with failure was the drug prescribed. DR failure occurred in 22\/39 (56.4%, 95% CI: 40.9%\u201370.6%) lomustine DRs, 14\/27 (51.9%, 95% CI: 33.9%\u201369.2%) cyclophosphamide DRs, but only 2\/22 (9.1%, 95% CI: 2.5%\u201327.8%) doxorubicin DRs and 2\/24 (8.3%, 95% CI: 2.3%\u201325.8%) vincristine DRs. Seventy\u2010three evaluable TDs (mean: 5\u2009days, SD\u2009\u00b1\u20092.2\u2009days) were prescribed. There was no association between TD duration and subsequent NEs (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.11).\n                  <\/jats:p>","DOI":"10.1111\/vco.13004","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T23:11:50Z","timestamp":1724281910000},"page":"542-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of 10% Dose Reductions and Duration of Treatment Delays in the Management of Chemotherapy\u2010Induced Neutropenia in Dogs Treated With Common Chemotherapy Protocols: A Single\u2010Centre Experience"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-1220","authenticated-orcid":false,"given":"Suzanne","family":"Busser","sequence":"first","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies The University of Edinburgh  Roslin UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9689-3645","authenticated-orcid":false,"given":"Laura","family":"Blackwood","sequence":"additional","affiliation":[{"name":"The Royal (Dick) School of Veterinary Studies The University of Edinburgh  Roslin UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Pereira","sequence":"additional","affiliation":[{"name":"Anicura Gl\u00f3ries Hospital Veterinari  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-333X","authenticated-orcid":false,"given":"Margo","family":"Chase\u2010Topping","sequence":"additional","affiliation":[{"name":"The Roslin Institute The University of Edinburgh  Roslin UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8050-0416","authenticated-orcid":false,"given":"Spela","family":"Bavcar","sequence":"additional","affiliation":[{"name":"Small Animal Specialist Hospital  North Ryde New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-9459","authenticated-orcid":false,"given":"Quentin","family":"Fournier","sequence":"additional","affiliation":[{"name":"AURA Veterinary  Guildford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.tcam.2009.02.004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.16875"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003\u20104819\u201064\u20102\u2010328"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11121387"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11882"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866\u2010023\u201003067\u20106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105829.2010.00222.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12163"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.1993.tb01021.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105829.2009.00199.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105829.2010.00224.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105829.2012.00318.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.14895"},{"key":"e_1_2_11_15_1","volume-title":"NICE Clinical Guidelines","author":"National Collaborating Centre for Cancer (UK)","year":"2012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/tpj.2017.23"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12544"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12001"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12894"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1892\/06\u2010197.1"},{"key":"e_1_2_11_21_1","unstructured":"Cancer Care Ontario \u201cDosage Modification for Hematologic and Non\u2010Hematologic Toxicities \u201d 2010 https:\/\/www.cancercareontario.ca\/sites\/ccocancercare\/files\/assets\/CCODoseModificationAppendix6.pdf."},{"key":"e_1_2_11_22_1","unstructured":"National Health Service \u201cChemotherapy Protocol Colorectal Cancer Capecitabine and Oxaliplatin (CAPOX) \u201d 2020 https:\/\/www.uhs.nhs.uk\/Media\/UHS\u2010website\u20102019\/Docs\/Chemotherapy\u2010SOPs1\/Colorectal\/Capecitabine\u2010Oxaliplatin.pdf."},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14614"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.9.2590"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2015.04.032"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2015.0166"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109343(80)90472\u20106"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.11.2042"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13822"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010015\u20100550\u2010x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12243"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12537"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476\u20105829.2012.00324.x"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.2004.tb00162.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.5326\/JAAHA\u2010MS\u20106315"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12465"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.42"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939\u20101676.1993.tb01013.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12622"},{"key":"e_1_2_11_40_1","unstructured":"J. A.Picornell J. B.Tanis S.Bavcar et al. \u201cEvaluation of Time to Neutropenic Nadir in Dogs Receiving Carboplatin: A Multicentric Retrospective Study \u201dAbstract Presented at: European Society of Veterinary Oncology Annual Congress 23\u201325th May 2024 Bucharest Romania."},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.283"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4143\/CRT.2021.010"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.13805"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12210"},{"issue":"1","key":"e_1_2_11_45_1","first-page":"11","article-title":"Serum Granulocyte Colony\u2010Stimulating Factor (G\u2010CSF) and Interleukin\u20101 (IL\u20101) Concentrations After Chemotherapy\u2010Induced Neutropenia in Normal and Tumor\u2010Bearing Dogs","volume":"24","author":"Bravo L.","year":"1996","journal-title":"Experimental Hematology"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277\u2010017\u20103191\u20107"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X8400400110"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.32406\/v3n62020\/105\u2010116\/agrariacad"},{"issue":"1","key":"e_1_2_11_49_1","first-page":"17","article-title":"Reference Intervals, Intraindividual and Interindividual Variability, and Reference Change Values for Hematologic Variables in Laboratory Beagles","volume":"54","author":"Bourg\u00e8s\u2010Abella N. H.","year":"2015","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00576"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12024"}],"container-title":["Veterinary and Comparative Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.13004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/vco.13004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/vco.13004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:38:20Z","timestamp":1780623500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/vco.13004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/vco.13004"],"URL":"https:\/\/doi.org\/10.1111\/vco.13004","archive":["Portico"],"relation":{},"ISSN":["1476-5810","1476-5829"],"issn-type":[{"value":"1476-5810","type":"print"},{"value":"1476-5829","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,21]]},"assertion":[{"value":"2023-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}