{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:21:15Z","timestamp":1782940875991,"version":"3.54.5"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Prostate cancer continues to be one of the most lethal cancers in men. While androgen deprivation therapy is initially effective in treating prostate cancer, most cases of advanced prostate cancer eventually progress to castration\u2010resistant prostate cancer (CRPC), which is incurable. Similarly, the most aggressive form of prostatic carcinoma occurs in dogs that have been castrated. To identify molecular similarities between canine prostate cancer and human CRPC, we performed a comparative analysis of gene expression profiles. Through this transcriptomic analysis, we found that prostatic carcinoma in castrated dogs demonstrates an androgen\u2010indifferent phenotype, characterised by low\u2010androgen receptor and neuroendocrine\u2010associated genes. Notably, we identified two genes,\n                    <jats:italic>ISG15<\/jats:italic>\n                    and\n                    <jats:italic>AZGP1<\/jats:italic>\n                    , that were consistently up\u2010 and down\u2010regulated, respectively, in both canine prostatic carcinoma and human CRPC. Additionally, we identified several other genes, including\n                    <jats:italic>GPX3<\/jats:italic>\n                    ,\n                    <jats:italic>S100P<\/jats:italic>\n                    and\n                    <jats:italic>IFITM1<\/jats:italic>\n                    , that exhibited similar expression patterns in both species. Protein\u2013protein interaction network analysis demonstrated that these five genes were part of a larger network of interferon\u2010induced genes, suggesting that they may act together in signalling pathways that are disrupted in prostate cancer. Accordingly, our findings suggest that the interferon pathway may play a role in the development and progression of CRPC in both dogs and humans and chart a new therapeutic approach.\n                  <\/jats:p>","DOI":"10.1111\/vco.13017","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T02:00:03Z","timestamp":1728352803000},"page":"629-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Comparative Transcriptomes of Canine and Human Prostate Cancers Identify Mediators of Castration Resistance"],"prefix":"10.1111","volume":"22","author":[{"given":"Marcela Riveros","family":"Angel","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"S\u00e9guin","sequence":"additional","affiliation":[{"name":"Flint Animal Cancer Center Colorado State University  Fort Collins Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane V.","family":"L\u00f6hr","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5600-9993","authenticated-orcid":false,"given":"Tomasz M.","family":"Beer","sequence":"additional","affiliation":[{"name":"Knight Cancer Institute Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Feliciano","sequence":"additional","affiliation":[{"name":"Veterinary Diagnostics &amp; Imaging Consultants  Tualatin Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2168-5403","authenticated-orcid":false,"given":"Stephen A.","family":"Ramsey","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Oregon State University  Corvallis Oregon USA"},{"name":"College of Engineering Oregon State University  Corvallis Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7416-8840","authenticated-orcid":false,"given":"George V.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Oregon Health and Science University  Portland Oregon USA"},{"name":"Knight Cancer Institute Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a030452"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30082-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2015.2895"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05821.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2011.02799.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22296"},{"issue":"3","key":"e_1_2_8_8_1","first-page":"365","article-title":"Mechanisms of Resistance in Castration\u2010Resistant Prostate Cancer (CRPC)","volume":"4","author":"Chandrasekar T.","year":"2015","journal-title":"Translational Andrology and Urology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2020.09.002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/vms3.642"},{"issue":"4","key":"e_1_2_8_11_1","article-title":"Molecular Similarities and Differences Between Canine Prostate Cancer and Human Prostate Cancer Variants","volume":"11","author":"Vasilatis D. 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