{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:01:58Z","timestamp":1780624918946,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005765","name":"Universidade de Lisboa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Melanoma is one of the most common canine oral malignant tumours and is highly aggressive and metastatic, even at the early stages of development. Surgery relies on wide excision of the primary tumour and regional lymphadenectomy, with or without adjuvant therapy. Tumour location and size are important when considering staging, which ultimately affects the curative intent of surgery. Nevertheless, absolute tumour volume (TV) is not related to the vast phenotypic variability within canine breeds. This study aimed to determine the cutoff values of two ratios\u2014tumour\u2010to\u2010head volume (THR) and tumour\u2010to\u2010body volume (TBR)\u2014and assess whether they could be associated with the odds of finding metastasis at presentation and\/or the likelihood of achieving tumour\u2010free excision margins. A retrospective case series involving 51 dogs was used to evaluate the preoperative head\/neck and chest computed tomography and histopathology of the primary mass and excised lymph nodes. Higher TV, THR% and TBR% values were associated with bone lysis and mitotic count (MC). The Ki67 index was significantly associated with local and distant metastases at presentation, whereas MC was associated with local metastasis alone. Tumour\u2010infiltrated surgical margins were associated with caudally located tumours, regardless of the tumour size. Dogs with lymph node metastasis at presentation were seven times more prone to have local relapse. TV, THR% and TBR% values were positively associated with local lymph node metastasis at presentation. Cutoff values for both TV and TBR% were proposed to predict lymph node metastasis at presentation (TV\u2009=\u20096.423\u2009cm\n                    <jats:sup>3<\/jats:sup>\n                    and TBR%\u2009=\u20090.043), being supported by post\u2010surgical survival analysis.\n                  <\/jats:p>","DOI":"10.1111\/vco.13018","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T01:49:16Z","timestamp":1728611356000},"page":"641-650","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relative Tumour Volume in Canine Oral Melanoma Staging and Prognosis"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9427-2562","authenticated-orcid":false,"given":"Marta L.","family":"Silva","sequence":"first","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine University of Lisbon  Lisbon Portugal"},{"name":"Clinical Department  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Martinho","sequence":"additional","affiliation":[{"name":"General Medicine Department  Almada Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Rocha","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Faculty of Veterinary Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Martano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Parma  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Spindler","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medical Sciences University of Parma  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Buracco","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Torino  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Giacobino","sequence":"additional","affiliation":[{"name":"Department of Veterinary Sciences University of Torino  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-5840","authenticated-orcid":false,"given":"Helena F.","family":"Florindo","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines (iMed. ULisboa), Faculty of Pharmacy University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-2106","authenticated-orcid":false,"given":"Lisa A.","family":"Mestrinho","sequence":"additional","affiliation":[{"name":"Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine University of Lisbon  Lisbon Portugal"},{"name":"Clinical Department  Lisbon Portugal"},{"name":"Veterinary Teaching Hospital, Faculty of Veterinary Medicine University of Lisbon  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ctsap.2007.03.004"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/vr.b4808"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcpa.2019.09.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.868004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.242.10.1392"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.245.11.1266"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12154"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12690"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/08987564211072396"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2005.00082.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.245.4.401"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.247.10.1146"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12122"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.15-0510"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12239"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004007"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cvsm.2005.03.005"},{"key":"e_1_2_10_19_1","unstructured":"P. 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