{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:54:40Z","timestamp":1783641280891,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Vet Comparative Oncology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Body composition measurements (BCM), obtained via computed tomography (CT), have been used as predictors of survival, tumour recurrence, and post\u2010surgical infections in human oncology. There are no reports on using BCM to predict outcomes of dogs with cancer. Elevated BCM is hypothesised to place extra stress on bones weakened by cancer. Pathologic fracture following stereotactic body radiation therapy for canine appendicular osteosarcoma (OSA) frequently results in limb amputation or euthanasia. Additional tools are needed to better predict the risk of fracture development. Our objectives were to determine if any relationships could be identified between BCM and the occurrence of a pathologic fracture and\/or survival time in dogs with naturally occurring OSA. Forty\u2010seven dogs with a confirmed OSA and whole\u2010body CT pre\u2010SBRT were included. Several BCM were evaluated, including abdominal volume, visceral adipose tissue volume, whole\u2010body volume, whole\u2010body adipose tissue volume, normalised cross\u2010sectional area of the epaxial muscles at the mid\u2010body of the 13th thoracic vertebra, and attenuations of adipose tissue and epaxial muscles. No BCMs were correlated with survival time. The volume of the entire body (cm<jats:sup>3<\/jats:sup>) was significantly positively associated with development of a fracture. No other BCM were correlated with the development of a fracture. The volume of the abdomen (cm<jats:sup>3<\/jats:sup>) among our patient subset was positively correlated with the volume of the entire body, and the volume of visceral adipose tissue (cm<jats:sup>3<\/jats:sup>) was positively correlated with the total body volume of adipose tissue (cm<jats:sup>3<\/jats:sup>). Additional research is needed to verify whether these findings are replicable in larger sample sizes and in prospective settings.<\/jats:p>","DOI":"10.1111\/vco.13037","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:03:29Z","timestamp":1735862609000},"page":"116-122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Body Composition Measurements as Predictive Variables for Outcomes of Canine Appendicular Osteosarcoma Treated With Stereotactic Body Radiation Therapy"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5872-099X","authenticated-orcid":false,"given":"Johnny","family":"Altwal","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Colorado Fort Collins US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-8233","authenticated-orcid":false,"given":"Lynn","family":"Griffin","sequence":"additional","affiliation":[{"name":"Advanced Animal Cancer Imaging LLC  Victoria British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-4861","authenticated-orcid":false,"given":"Tiffany Wormhoudt","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences Colorado State University  Colorado Fort Collins US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-2362-5.00024-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(96)50011-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2021.734965"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5810.2005.00062.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.69.9.1197"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2004.225.1567"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12674"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.55.4675"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.12351"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vco.12877"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/vsu.12669"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-950X.2014.12082.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2020.1800087"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4306-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185117723370"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.12.030"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12379"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26793"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.10.021"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/50.5.1231"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.suppl_2.465"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.5.992S"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.73.11.1794"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2617-1619.2018.tb00006.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.011"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13020453"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15020485"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-019-03322-w"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/rco2.56"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-018-1768-6"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/vru.13361"},{"key":"e_1_2_10_33_1","volume-title":"Applied Statistics for the Behavioral Sciences","author":"Hinkle D. 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